| Hesperetin: a potent antioxidant against peroxynitrite. | |
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MedLine Citation:
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PMID: 15453641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peroxynitrite (ONOO-) is a reactive oxidant formed from superoxide (*O2(-)) and nitric oxide (*NO), that can oxidize several cellular components, including essential protein, non-protein thiols, DNA, low-density lipoproteins (LDL), and membrane phospholipids. ONOO- has contributed to the pathogenesis of diseases such as stroke, heart disease, Alzheimer's disease, and atherosclerosis. Because of the lack of endogenous enzymes to thwart ONOO- activation, developing a specific ONOO- scavenger is remarkably important. In this study, the ability of hesperetin (3',5,7-trihydroxy-4-methoxyflavanone) to scavenge ONOO- and to protect cells against ONOO- and ROS was investigated. The data gained show that hesperetin can efficiently scavenge authentic ONOO- . In spectrophotometric analysis, the data revealed that hesperetin led to declined ONOO- -mediated nitration of tyrosine through electron donation. Hesperetin exhibited significant inhibition on the nitration of bovine serum albumin (BSA) by ONOO- in a dose-dependent manner. Hesperetin also manifested cytoprotection from cell damage induced by ONOO- and ROS. The present study suggests that hesperetin is a powerful ONOO- scavenger and promotes cellular defense activity in the protection against ONOO- involved diseases. |
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Authors:
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Ji Young Kim; Kyung Jin Jung; Jae Sue Choi; Hae Young Chung |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 38 ISSN: 1071-5762 ISO Abbreviation: Free Radic. Res. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-09-29 Completed Date: 2005-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 761-9 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung-gu, Busan 609-735, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / chemistry, metabolism, pharmacology* Cell Line Free Radical Scavengers / chemistry, metabolism, pharmacology Hesperidin / chemistry, metabolism, pharmacology* Nitric Oxide / chemistry, metabolism Peroxynitrous Acid / biosynthesis, metabolism* Rats Reactive Oxygen Species / metabolism Serum Albumin, Bovine / chemistry, metabolism Superoxides / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 0/Serum Albumin, Bovine; 10102-43-9/Nitric Oxide; 11062-77-4/Superoxides; 14691-52-2/Peroxynitrous Acid; 520-26-3/Hesperidin; 520-33-2/hesperetin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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