| Hervey, Harris, and the Parabiotic Search for Lipostatic Signals. | |
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MedLine Citation:
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PMID: 22983368 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This paper is an introduction to the papers by Hervey and Harris that describe their experimental use of parabiosis in rats and mice to search for circulating lipostatic signals. Beginning in 1959 with Hervey's foundational paper, they detected three parabiotic signals: the Hervey signal decreases food intake and fat mass in rats; the antilipogenic factor (ALF) decreased fat mass, but not food intake in rats; and the leptin-dependent signal in lean partners of ob/ob mice decreased fat mass, but not food intake. The known lipostatic signals, leptin and insulin, have been candidates for the Hervey and ALF signals, but insulin has been excluded and the evidence for leptin is inconclusive. The site of production of the three parabiotic signals and their molecular structure are not known and specific mechanisms of their lipostatic control are incompletely understood. Given their potential importance for understanding the physiology of lipostatic controls and for developing new therapies for obesity, Hervey and Harris make a strong argument for further research on the three parabiotic signals. |
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Authors:
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Gerard P Smith |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-13 |
Journal Detail:
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Title: Appetite Volume: - ISSN: 1095-8304 ISO Abbreviation: Appetite Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006808 Medline TA: Appetite Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Department of Psychiatry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065. Electronic address: gpsmith@med.cornell.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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