Document Detail


Herpes virus infections occur frequently following treatment with fludarabine: results of a prospective natural history study.
MedLine Citation:
PMID:  10233419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed a prospective infectious natural history study of 21 patients with low-grade lymphoproliferative disorders receiving fludarabine as initial (n = 5) or salvage (n = 16) therapy. 12 (57%) of these patients developed herpes zoster (n = 9), herpes simplex I (n = 1) or herpes simplex II (n = 2) infections at a median of 8 (range 1-17) months following initiation of fludarabine, with 75% of these having completed therapy. All patients with herpes zoster developed severe post-herpetic neuralgia. Factors differentiating patients developing these infections included older age and low serum IgG or IgA. Based upon these prospective data, we conclude that herpes virus infections frequently occur following fludarabine treatment, necessitating aggressive patient education and new prophylactic strategies.
Authors:
J C Byrd; L H McGrail; D R Hospenthal; R S Howard; N A Dow; L F Diehl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  105     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-24     Completed Date:  1999-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  445-7     Citation Subset:  IM    
Affiliation:
Hematology-Oncology Service, Divison of Hematologic Malignancies, Johns Hopkins Oncology Center, Baltimore, Maryland, USA. john_c.byrd@wramaa.chcs.amedd.army.mil
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Herpesviridae Infections / chemically induced*,  complications
Humans
Immunosuppressive Agents / adverse effects*
Lymphoproliferative Disorders / complications,  drug therapy*
Male
Middle Aged
Opportunistic Infections / complications*
Prospective Studies
Vidarabine / adverse effects,  analogs & derivatives*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 21679-14-1/fludarabine; 5536-17-4/Vidarabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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