| Herpes simplex virus type 2 trends in relation to the HIV epidemic in northern Malawi. | |
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MedLine Citation:
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PMID: 18524842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: It is unclear whether the high prevalence of herpes simplex virus type 2 (HSV-2) found in much of Africa predates the HIV epidemic or is, to some extent, a consequence of it. HSV-2 prevalence trends in a rural African community were assessed over a period in which HIV prevalence rose sharply, and antenatal clinic (ANC) surveillance was explored as a method of estimating community HSV-2 prevalence. METHODS: HSV-2 seroprevalence was determined among community controls seen for case-control studies of mycobacterial disease in Karonga district, Malawi, in 1988-90, 1998-2001 and 2002-5, and in women attending ANC as part of surveillance for HIV in 1999-2000. Over this period HIV prevalence rose from 4% to 12%. RESULTS: HSV-2 prevalence in all periods increased sharply with age and was higher in women than in men. After excluding migrants, there was no evidence of change in HSV-2 prevalence in the different periods. Women in the ANC group had lower HSV-2 prevalence than those in the community, but the ANC prevalence was a good approximation to the combined male and female prevalence for the same age group. CONCLUSIONS: This study suggests that HSV-2 was already widespread before the HIV epidemic and has not been greatly influenced by it. It also demonstrates that ANC surveillance may be useful for estimating community HSV-2 prevalence. |
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Authors:
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J R Glynn; A C Crampin; B M M Ngwira; R Ndhlovu; O Mwanyongo; P E M Fine |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-04 |
Journal Detail:
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Title: Sexually transmitted infections Volume: 84 ISSN: 1472-3263 ISO Abbreviation: Sex Transm Infect Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2008-10-27 Revised Date: 2011-12-26 |
Medline Journal Info:
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Nlm Unique ID: 9805554 Medline TA: Sex Transm Infect Country: England |
Other Details:
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Languages: eng Pagination: 356-60 Citation Subset: IM |
Affiliation:
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Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E7HT, UK. judith.glynn@lshtm.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Female HIV Infections / complications, epidemiology* Herpes Genitalis / complications, epidemiology* Herpesvirus 2, Human* Humans Malawi / epidemiology Male Middle Aged Prevalence Rural Health Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
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079828//Wellcome Trust; //Department of Health |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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