Document Detail

Herpes simplex virus prophylaxis with famciclovir in patients undergoing aesthetic facial CO2 laser resurfacing.
MedLine Citation:
PMID:  14604087     Owner:  NLM     Status:  MEDLINE    
Herpes simplex virus 1 (HSV-1) reactivation may occur in patients undergoing facial carbon dioxide (CO2) laser resurfacing and can delay healing and result in severe scarring. Prophylactic oral antiviral agents are administered routinely to patients undergoing laser resurfacing to prevent postoperative HSV-1 eruptions; however, dosage and duration of treatment vary in the literature. Famciclovir is a highly effective nucleoside analog used in the treatment of HSV infections. In this study, 60 patients, with and without a prior history of facial HSV-1 outbreaks, were given famciclovir 250 mg twice a day (BID), starting the day before facial laser resurfacing and continuing for 14 days. No reactivation was observed in any of the patients. In this small study, famciclovir 250 mg given BID for 14 days was an effective prophylactic treatment in facial laser resurfacing patients for the prevention of facial HSV reactivation.
Emil Bisaccia; Dwight Scarborough
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cutis     Volume:  72     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-03-26     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-8     Citation Subset:  IM    
Columbia University, College of Physicians and Surgeons, New York, New York, USA.
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MeSH Terms
2-Aminopurine / analogs & derivatives*,  therapeutic use*
Anti-Bacterial Agents / therapeutic use
Antibiotic Prophylaxis*
Antiviral Agents / therapeutic use*
Carbon Dioxide / therapeutic use
Cephalexin / therapeutic use
Herpes Simplex / therapy*,  virology*
Herpesvirus 1, Human*
Laser Therapy* / methods
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antiviral Agents; 104227-87-4/famciclovir; 124-38-9/Carbon Dioxide; 15686-71-2/Cephalexin; 452-06-2/2-Aminopurine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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