| Herpes simplex virus prophylaxis with famciclovir in patients undergoing aesthetic facial CO2 laser resurfacing. | |
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MedLine Citation:
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PMID: 14604087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herpes simplex virus 1 (HSV-1) reactivation may occur in patients undergoing facial carbon dioxide (CO2) laser resurfacing and can delay healing and result in severe scarring. Prophylactic oral antiviral agents are administered routinely to patients undergoing laser resurfacing to prevent postoperative HSV-1 eruptions; however, dosage and duration of treatment vary in the literature. Famciclovir is a highly effective nucleoside analog used in the treatment of HSV infections. In this study, 60 patients, with and without a prior history of facial HSV-1 outbreaks, were given famciclovir 250 mg twice a day (BID), starting the day before facial laser resurfacing and continuing for 14 days. No reactivation was observed in any of the patients. In this small study, famciclovir 250 mg given BID for 14 days was an effective prophylactic treatment in facial laser resurfacing patients for the prevention of facial HSV reactivation. |
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Authors:
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Emil Bisaccia; Dwight Scarborough |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cutis; cutaneous medicine for the practitioner Volume: 72 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-11-07 Completed Date: 2004-03-26 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006440 Medline TA: Cutis Country: United States |
Other Details:
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Languages: eng Pagination: 327-8 Citation Subset: IM |
Affiliation:
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Columbia University, College of Physicians and Surgeons, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Aminopurine
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analogs & derivatives*,
therapeutic use* Anti-Bacterial Agents / therapeutic use Antibiotic Prophylaxis* Antiviral Agents / therapeutic use* Carbon Dioxide / therapeutic use Cephalexin / therapeutic use Esthetics* Herpes Simplex / therapy*, virology* Herpesvirus 1, Human* Humans Laser Therapy* / methods Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antiviral Agents; 104227-87-4/famciclovir; 124-38-9/Carbon Dioxide; 15686-71-2/Cephalexin; 452-06-2/2-Aminopurine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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