Document Detail

Herpes simplex virus infections in the neonate.
MedLine Citation:
PMID:  7576893     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the experience of the Camperdown Children's Hospital with neonatal herpes simplex viral (HSV) infections between 1960 and 1992. DESIGN: A retrospective record review of all cases of HSV infection. RESULTS: Fifteen proven HSV infections were found. Only three cases had a definite history of HSV infection during pregnancy. Six were delivered at 36 weeks gestation or earlier. Seven weighed 2500 g or less. Forty-three per cent developed physical signs within 7 days of birth. Three cases were confined to skin, eyes and mouth, five were generalized, six had encephalitis with or without skin lesions, and one had pneumonitis. The mortality rate comprising the five with generalized infection was 47%, one with encephalitis and the one with pneumonitis. Four of the eight survivors have persisting neurological impairment. Those with disseminated infection and encephalitis did poorly regardless of antiviral treatment. CONCLUSION: A high index of suspicion of HSV infection is important so that antiviral treatment can be commenced early, particularly for those infections localized to skin, eye and mouth where there may be a good prognosis.
D J Malouf; R K Oates
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  31     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  332-5     Citation Subset:  IM    
Sydney University Department of Paediatrics and Child Health, Children's Hospital, Camperdown, New South Wales, Australia.
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MeSH Terms
Birth Weight
Herpes Simplex / congenital*,  diagnosis,  epidemiology,  prevention & control,  therapy,  transmission
Herpesvirus 1, Human / isolation & purification
Herpesvirus 2, Human / isolation & purification
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control
New South Wales / epidemiology
Pregnancy Complications, Infectious / epidemiology

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