Document Detail

Herpes simplex virus-1 encephalitis: a review of current disease management with three case reports.
MedLine Citation:
PMID:  23018202     Owner:  NLM     Status:  MEDLINE    
Herpes simplex virus-1 (HSV-1) is the most common cause of lethal sporadic encephalitis. Despite improved therapy with intraveneous acyclovir, HSV-1 encephalitis is associated with persistent severe neurological deficits. We report three cases of adult patients with HSV-1 encephalitis (HSE), discuss the current accepted guidelines for treatment as published by the Infectious Disease Society of America (IDSA) and review the literature pertaining to HSE. Our case presentations are consistent with the literature review noting a broad spectrum of clinical outcomes with HSE. We include the first published case of successful early transition to oral antiviral therapy. In the other two cases, repeat cerebrospinal fluid (CSF) analysis showed persistent lymphocytic pleocytosis necessitating prolonged viral suppression. Long-term neurological sequelae were noted in these two patients. The IDSA recommendation of 2-3 weeks of intraveneous acyclovir at 10 mg/kg every 8 h, depending on the clinical course, is sufficient for most cases of HSE. We recommend individualization of duration of treatment based on follow-up CSF analysis with quantification of HSV-1.
Michael J Skelly; Andrew A Burger; Oritsegbubemi Adekola
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-09-25
Journal Detail:
Title:  Antiviral chemistry & chemotherapy     Volume:  23     ISSN:  2040-2066     ISO Abbreviation:  Antivir. Chem. Chemother.     Publication Date:  2013  
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-03-11     Revised Date:  2014-01-28    
Medline Journal Info:
Nlm Unique ID:  9009212     Medline TA:  Antivir Chem Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
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MeSH Terms
Acyclovir / administration & dosage,  therapeutic use*
Antiviral Agents / administration & dosage,  therapeutic use*
Cerebrospinal Fluid / drug effects,  virology
Encephalitis, Herpes Simplex / drug therapy*,  virology
Herpesvirus 1, Human / drug effects*
Middle Aged
Reg. No./Substance:
0/Antiviral Agents; X4HES1O11F/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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