| Herpes simplex virion entry into and intracellular transport within mammalian cells. | |
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MedLine Citation:
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PMID: 14597143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alphaherpesviruses, membrane-enveloped DNA viruses that are responsible for a host of human ailments, bind to, enter and are directly targeted to specific intracellular domains within their mammalian host cells. This review emphasizes recent work on the best studied of the alphaherpesviruses, Herpes simplex virus type 1 (HSV1). One area of focus is on recent work that has identified viral glycoproteins that are important in binding and internalization of the virus to the host cell. Complementary work on the receptors for those viral glycoproteins that reside on the host cell surface is also presented, with some discussion of how receptor variety might lead to the tissue tropism demonstrated by alphaherpes viruses. An additional area of focus in this review is how HSV uses the host cell transport systems to achieve intracellular targeting of the incoming virion toward the cell nucleus, and, after production of newly synthesized and assembled viral progeny, targeting them toward the plasma membrane for release. |
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Authors:
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Judy A Garner |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 55 ISSN: 0169-409X ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-04 Completed Date: 2004-07-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1497-513 Citation Subset: IM |
Affiliation:
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Department of Cell and Neurobiology, BMT 401, Keck School of Medicine at USC, 1333 San Pablo St., Los Angeles, CA 90089, USA. jgarner@usc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Cell Membrane / physiology Cell Nucleus / metabolism Endocytosis Herpesviridae Infections / virology Herpesvirus 1, Human / metabolism, physiology* Humans Membrane Fusion Protein Binding Viral Envelope Proteins / metabolism, physiology Virion / metabolism, physiology |
| Grant Support | |
ID/Acronym/Agency:
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NS38246/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Viral Envelope Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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