Document Detail

Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: Varicella-zoster virus infections.
MedLine Citation:
PMID:  17180380     Owner:  NLM     Status:  MEDLINE    
Varicella during pregnancy can be associated with severe illnesses for both the mother and her neonate. Varicella pneumonia must be regarded as a medical emergency, since pregnant women are at risk of life-threatening ventilatory compromise and death. After maternal chickenpox in the first and second trimesters, congenital varicella syndrome may occur in nearly 2% of the cases. The characteristic symptoms consist of skin lesions in dermatomal distribution, neurological defects, eye diseases and skeletal anomalies. If the mother develops varicella rashes between day 4 (5) antepartum and day 2 postpartum, generalized neonatal varicella leading to death in about 20% of the cases has to be expected. Normal zoster has not been shown to be associated with maternal pneumonia, birth defects or problems in the perinatal period. On the basis of the clinical consequences of varicella-zoster virus infections during pregnancy, the present paper summarizes the currently available concepts of prevention, diagnosis and therapy.
A Sauerbrei; P Wutzler
Publication Detail:
Type:  Journal Article; Review     Date:  2006-12-16
Journal Detail:
Title:  Medical microbiology and immunology     Volume:  196     ISSN:  0300-8584     ISO Abbreviation:  Med. Microbiol. Immunol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0314524     Medline TA:  Med Microbiol Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University of Jena, Hans-Knoell-Strasse 2, 07745 Jena, Germany.
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MeSH Terms
Acyclovir / therapeutic use*
Antiviral Agents / therapeutic use*
Chickenpox* / diagnosis,  drug therapy,  prevention & control,  transmission
Herpesvirus 3, Human / pathogenicity*,  physiology
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control
Pneumonia, Viral
Pregnancy Complications, Infectious* / diagnosis,  drug therapy,  prevention & control
Reg. No./Substance:
0/Antiviral Agents; 59277-89-3/Acyclovir

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