| Herpes simplex esophagitis in patients with AIDS: report of 34 cases. The Cooperative Study Group on Herpetic Esophagitis in HIV Infection. | |
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MedLine Citation:
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PMID: 8783688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herpetic esophagitis (HE) associated with human immunodeficiency virus (HIV) is a rare condition mainly reported as isolated cases. We thus decided to study this association and analyze the possible predisposing factors, clinical and endoscopic presentations, and clinical response to treatment. Thirty-four HIV-1-infected patients were identified: 27 had histologically or virologically confirmed HE and seven had probable HE, a retrospective diagnosis based on the efficacy of acyclovir given alone. The median CD4 cell count was 15/mm3. Recent predisposing factors (such as nasogastric procedures, steroid therapy, and anticancer therapy) were noted with regard to 16 of the 34 patients (47%). Odynophagia and/or chest pain occurred in 30 patients (88%). At the time of diagnosis of HE, extraesophageal herpes was found in only 13 patients (38%). Superficial ulcers of the distal third of the esophagus were present in 17 (50%). Among 20 of the 27 patients with confirmed HE that could be evaluated, therapy with acyclovir led to complete resolution in 16 and partial response in 3; 1 patient died of HE. Five patients (15%) suffered confirmed or possible relapses. The mean interval between the diagnosis of HE and death was 8.8 months. Herpes simplex virus may be responsible for ulcerated esophagitis that occurs in the advanced stages of AIDS and that can be safely treated with acyclovir before a definitive diagnosis is made. |
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Authors:
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T Généreau; O Lortholary; O Bouchaud; F Lacassin; P Vinceneux; P De Truchis; A Jaccard; J L Meynard; R Verdon; D Sereni; C Marche; J P Coulaud; L Guillevin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 22 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1997-01-08 Completed Date: 1997-01-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 926-31 Citation Subset: IM; X |
Affiliation:
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Service de Médecine Interne, Hôpital Avicenne, Université Paris-Nord, Bobigny, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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microbiology* Acquired Immunodeficiency Syndrome / complications* Acyclovir / therapeutic use Adrenal Cortex Hormones / adverse effects Adult Aged Antineoplastic Agents / adverse effects CD4 Lymphocyte Count Esophagitis / complications*, diagnosis, drug therapy Esophagoscopy Female Herpes Simplex / etiology*, immunology Humans Intubation, Gastrointestinal / adverse effects Male Middle Aged Recurrence Retrospective Studies Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Antineoplastic Agents; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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