Document Detail

Herpes simplex encephalitis following microvascular decompression for trigeminal neuralgia.
MedLine Citation:
PMID:  23289817     Owner:  NLM     Status:  MEDLINE    
The authors present the first reported case of herpes simplex encephalitis (HSE) precipitated by trigeminal nerve microvascular decompression (MVD). The presentation of this specific case together with the pathogenesis and management of HSE are discussed, with a relevant literature review. This 29-year-old woman with treatment-resistant trigeminal neuralgia underwent a successful elective MVD of the right trigeminal nerve. She was discharged but was readmitted 1 week postoperatively with clinical signs and symptoms of meningitis. A CSF sample was obtained through lumbar puncture before she was treated initially with ceftriaxone. The polymerase chain reaction test of CSF was later positive for herpes simplex virus Type 1, at which point the patient was switched to a 2-week course of intravenous acyclovir before being discharged. Although this disease is rare, to avoid a delay in antiviral treatment the authors suggest that HSE should be considered in any patient presenting with a meningoencephalitic picture following MVD.
Hon Tang; Francisco Falcone; Sam Eljamel
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2013-01-04
Journal Detail:
Title:  Journal of neurosurgery     Volume:  118     ISSN:  1933-0693     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-04-22     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  530-3     Citation Subset:  AIM; IM    
Department of Neurosurgery, Ninewells Hospital and Medical School, Dundee, United Kingdom.
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MeSH Terms
Acyclovir / administration & dosage,  therapeutic use*
Antiviral Agents / administration & dosage,  therapeutic use*
Cerebrospinal Fluid / virology
Encephalitis, Herpes Simplex / diagnosis*,  drug therapy,  etiology*
Herpesvirus 1, Human / isolation & purification
Infusions, Intravenous
Magnetic Resonance Imaging
Microvascular Decompression Surgery / adverse effects*
Spinal Puncture
Trigeminal Neuralgia / surgery*
Reg. No./Substance:
0/Antiviral Agents; 59277-89-3/Acyclovir
Comment In:
J Neurosurg. 2013 Jun;118(6):1386
J Neurosurg. 2013 Jun;118(6):1385-6   [PMID:  23621594 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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