Document Detail


Herpes gestationis. Immunopathology and characterization of the HG factor.
MedLine Citation:
PMID:  819458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five patients with herpes gestationis, a blistering disease of pregnancy, were studied immunologically. All had in vivo deposition of C3 in a linear band along the basement membrane zone of lesional and normal-appearing skin, the location of early blister formation. Immunoglobulin deposition was more variable, though four patients had evidence of in vivo bound IgG at the same site. A circulating, complement binding herpes gestationis factor was demonstrated in the sera of four of the patients, its concentration unrelated to the activity of clinical disease. Characterization of this factor by sucrose gradient ultracentrifugation, specific absorption studies, and papain digestion indicates that it is an IgG. Evidence exists for involvement of both the classical and alternate complement pathways in vivo, though in vitro studies implicate the classical pathway as the primary route of complement activation. Three offspring were studied, none with clinical involvement; one showed in vivo deposition of C3 at the basement membrane zone of normal skin and a second showed the herpes gestationis factor in cord blood.
Authors:
S I Katz; K C Hertz; H Yaoita
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  57     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-23     Completed Date:  1976-08-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1434-41     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Adult
Animals
Antibodies / analysis
Antibodies, Viral / analysis
Basement Membrane / immunology
Complement C3*
Complement C4 / deficiency
Complement System Proteins*
Edetic Acid / pharmacology
Egtazic Acid / pharmacology
Female
Fluorescent Antibody Technique
Guinea Pigs
Humans
Immunoglobulin G / metabolism
Papain / pharmacology
Pemphigoid Gestationis / immunology*,  pathology
Pemphigus / immunology
Pregnancy
Pregnancy Complications / immunology*
Skin Diseases, Vesiculobullous / immunology*
Ultracentrifugation
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Viral; 0/Complement C3; 0/Complement C4; 0/Immunoglobulin G; 60-00-4/Edetic Acid; 67-42-5/Egtazic Acid; 9007-36-7/Complement System Proteins; EC 3.4.22.2/Papain
Comments/Corrections

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