Document Detail


Heroin reduces startle and cortisol response in opioid-maintained heroin-dependent patients.
MedLine Citation:
PMID:  20331562     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Heroin dependence (HD) is a chronic relapsing brain disorder characterized by a compulsion to seek and use heroin. Stress is seen as a key factor for heroin use. Methadone maintenance and the prescription of pharmaceutical heroin [diacetylmorphine (DAM)] are established treatments for HD in several countries. The present study examined whether DAM-maintained patients and methadone-maintained patients differ from healthy controls in startle reflex and cortisol levels. Fifty-seven participants, 19 of each group matched for age, sex and smoking status, completed a startle session which included the presentation of 24 bursts of white noise while eye-blink responses to startling noises were recorded. Salivary cortisol was collected three times after awakening, before, during and after the startle session. DAM was administered before the experiment, while methadone was administered afterwards. Both heroin-dependent patient groups exhibited significantly smaller startle responses than healthy controls (P < 0.05). Whereas the cortisol levels after awakening did not differ across the three groups, the experimental cortisol levels were significantly lower in DAM-maintained patients, who received their opioid before the experiment, than in methadone-maintained patients and healthy controls (P < 0.0001). Opioid maintenance treatment for HD is associated with reduced startle responses. Acute DAM administration may suppress cortisol levels, and DAM maintenance treatment may represent an effective alternative to methadone in stress-sensitive, heroin-dependent patients.
Authors:
Marc Walter; Gerhard A Wiesbeck; Bigna Degen; Jürgen Albrich; Monika Oppel; André Schulz; Hartmut Schächinger; Kenneth M Dürsteler-MacFarland
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Addiction biology     Volume:  16     ISSN:  1369-1600     ISO Abbreviation:  Addict Biol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9604935     Medline TA:  Addict Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-51     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors, Addiction Biology © 2010 Society for the Study of Addiction.
Affiliation:
Psychiatric Hospital, University of Basel, Switzerland. marc.walter@upkbs.ch
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