Document Detail


Herlitz junctional epidermolysis bullosa: a case report and review of current diagnostic methods.
MedLine Citation:
PMID:  9263316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report an infant with Herlitz junctional epidermolysis bullosa (JEB) presenting at birth with erosions on the scalp, thigh and periumbilical area in addition to nail abnormalities. Ultrastructural studies demonstrated a split through the lamina lucida with poorly formed hemidesmosomes and no clearly defined subbasal dense plates. Indirect immunofluorescence staining with antibodies GB3 (antilaminin 5) and 19-DEJ-1 (antiuncein) was totally absent. These findings, in combination with the clinical picture, favor a diagnosis of Herlitz JEB. Immunohistochemistry findings greatly facilitated an accurate diagnosis, which is essential in view of the poor prognosis for patients with this form of junctional epidermolysis bullosa.
Authors:
T Basarab; M G Dunnill; R A Eady; R Russell-Jones
Related Documents :
3021106 - Subcutaneous clostridial infection in broilers.
1006156 - Prevalence of antral and fundic gastritis in a randomly selected group of an estonian r...
8585556 - Goldenhar sequence and mosaic trisomy 22.
18683186 - A procedure for the measurement of infant skin conductance and its initial validation u...
7602556 - Confidential inquiries into cot deaths in british forces germany.
2608226 - Maori and nonmaori postneonatal mortality rates by domicile.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  14     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-09-24     Completed Date:  1997-09-24     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Ealing Hospital NHS Trust, Middlesex, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Epidermolysis Bullosa, Junctional / diagnosis*,  pathology
Female
Humans
Immunohistochemistry
Infant, Newborn
Microscopy, Electron
Skin / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Linear IgA disease with clinical and immunopathological features of epidermolysis bullosa acquisita.
Next Document:  Congenital Wells syndrome.