| Heritable translocation and dominant-lethal mutation induction with ethylene oxide in mice. | |
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MedLine Citation:
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PMID: 7254215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethylene oxide was studied for induction of dominant-lethal mutations and heritable translocations in male mice. The chemical was prepared in water and injected intraperitoneally. The dominant-lethal study was conducted using a single injection of 150 mg/kg (maximum tolerated dose); in the heritable translocation study males were injected daily on weekdays for 5 weeks with 60 or 30 mg/kg dose per day. Results clearly showed that ethylene oxide is effective in inducing dominant-lethal mutations and that the 4 stocks of untreated females used do not differ or may differ only slightly in the ability of their eggs to repair ethylene oxide-induced lesions in male germ cells. Increases in the frequencies of heritable translocations were also observed at the 2-dose levels. These frequencies did not deviate significantly from those expected on the basis of dose-square kinetics. |
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Authors:
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W M Generoso; K T Cain; M Krishna; C W Sheu; R M Gryder |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Mutation research Volume: 73 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1980 Nov |
Date Detail:
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Created Date: 1981-09-25 Completed Date: 1981-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 133-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA Repair Ethylene Oxide / administration & dosage, pharmacology* Female Genes, Dominant / drug effects Genes, Lethal / drug effects Male Mice Mutation* Ovum / enzymology Translocation, Genetic / drug effects* |
| Chemical | |
Reg. No./Substance:
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75-21-8/Ethylene Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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