Document Detail


Heritable, diet-induced hyperlipidemia in California mice (Peromyscus californicus) is due to increased hepatic secretion of very low density lipoprotein triacylglycerol.
MedLine Citation:
PMID:  17219776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
California mice (Peromyscus californicus) develop type II diabetes mellitus when fed a high-fat diet. We undertook the current studies to determine whether hyperlipidemia precedes the development of insulin resistance and to establish breeding colonies of hyperlipidemic and normolipidemic mice. For 6 wk, mice (n = 24) received a diet containing 25.8% of energy from fat. Mice representing the upper and lower quartiles of serum triacylglycerol (TAG) response (mean, >1000 mg/dl versus <300 mg/dl, respectively; 6 mice per group) were designated as high (HR) and low (LR) responders, respectively, and were used for further study. After 12 wk of consuming the high-fat diet, HR mice remained hypertriglyceridemic and developed hyperinsulinemia (5.1 +/- 1.3 ng/ml), hypercholesterolemia (309.3 +/- 31.0 mg/dl), and hyperglycemia (205.9 +/- 30.3 mg/dl) compared with LR mice. HR mice were not hyperphagic or obese. Offspring of HR x HR mice had elevated serum TAG concentrations (mean, 1752.2 +/- 209.7 mg/dl), hypercholesterolemia, hyperinsulinemia, and mild hyperglycemia by 5.5 mo of age. Mating HR male and LR female mice produced HR, intermediate, and LR progeny. HR mice had elevated serum concentrations of cholesterol, and plasma concentrations of high density lipoprotein cholesterol, and the very low density lipoprotein TAG compared with LR mice. Lipoprotein lipase and hepatic lipase activities did not differ between HR and LR mice. Studies of in vivo hepatic TAG production indicated that the hyperlipidemia of HR mice is a consequence of TAG hypersecretion.
Authors:
Lisa Krugner-Higby; Gregory S Shelness; Allyson Holler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Comparative medicine     Volume:  56     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-02-20     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-75     Citation Subset:  IM    
Affiliation:
The Research Animal Resources Center, University of Wisconsin-Madison, Madison, Wisconsin, USA. lisakh@rarc.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Breeding
Dietary Fats / administration & dosage
Disease Models, Animal
Female
Hyperlipidemias / etiology*,  genetics,  physiopathology
Lipase / metabolism
Lipids / blood
Lipoprotein Lipase / metabolism
Lipoproteins, VLDL / blood,  secretion*
Liver / secretion*
Male
Peromyscus*
Triglycerides / blood,  secretion*
Grant Support
ID/Acronym/Agency:
HL49373/HL/NHLBI NIH HHS; HL59247/HL/NHLBI NIH HHS; R03AG18551/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Lipids; 0/Lipoproteins, VLDL; 0/Triglycerides; 0/very low density lipoprotein triglyceride; EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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