Document Detail

Heritable components of feline hematology, clinical chemistry, and acid-base profiles.
MedLine Citation:
PMID:  17158462     Owner:  NLM     Status:  MEDLINE    
Four erythrocyte variables (erythrocyte count, hemoglobin, mean cell volume, packed cell volume), 14 serum variables (alanine transferase, albumin, alkaline phosphatase, calcium, chloride, cholesterol, creatinine, glucose, phosphorus, potassium, sodium, total protein, triglycerides, urea nitrogen), and 7 venous acid-base variables (base excess, bicarbonate, carbon dioxide partial pressure, oxygen partial pressure, oxygen saturation, pH, and total carbon dioxide) were evaluated for heritability in domestic cats (Felis catus). Values used for individual cats were expressed as the mean over all lifetime measurements, using 444-530 animals for clinical chemistry, 629 animals for acid-base, and 564 animals for erythrocyte metrics. Gender and age at death (where applicable) also were evaluated for correlation with variables. Heritabilities for clinical chemistry, acid-base, and erythrocyte variables ranged, respectively, from 0.13 to 0.78, from 0.23 to 0.59, and from 0.41 to 0.69 (P < 0.05). This result indicates that serum variability has a genetic basis and is segregating in this feline population. These findings may have important implications in both research and clinical medicine.
Dennis F Lawler; Kevin Chase; Robert Teckenbrock; Karl G Lark
Publication Detail:
Type:  Journal Article     Date:  2006-12-08
Journal Detail:
Title:  The Journal of heredity     Volume:  97     ISSN:  0022-1503     ISO Abbreviation:  J. Hered.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375373     Medline TA:  J Hered     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-54     Citation Subset:  IM    
Nutrition Research Center, Nestle Purina Company, Checkerboard Square, St Louis, MO 63164, USA.
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MeSH Terms
Acid-Base Equilibrium / genetics
Age Factors
Alkaline Phosphatase / blood,  genetics
Blood Chemical Analysis / veterinary
Blood Glucose / genetics,  metabolism
Cats / blood*,  genetics*
Cholesterol / blood,  genetics
Creatinine / blood
Erythrocyte Indices / genetics,  veterinary
Hematologic Tests / veterinary
Triglycerides / blood,  genetics
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 57-88-5/Cholesterol; 60-27-5/Creatinine; EC Phosphatase

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