Document Detail


Heritable anomalies among the inhabitants of regions of normal and high background radiation in Kerala: results of a cohort study, 1988-1994.
MedLine Citation:
PMID:  15346682     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a genetic epidemiological and fertility survey among 70,000 inhabitants in a high-background radiation region (HBRR) and normal radiation region (NRR) in Kerala, India, 985 persons were found to have heritable anomalies. Suggested etiologies for the anomalies were chromosomal and Mendelian, 15 percent; multifactorial, 60 percent; and congenital, 25 percent. There was a statistically significant increase of Down syndrome, autosomal dominant anomalies, and multifactorial diseases and an insignificant increase of autosomal recessive and X-linked recessive anomalies in the HBRR. The total fertility rate was 3.85 per couple; 9 percent of live-born children were reported dead. The rate of untoward pregnancy outcome--death of the offspring or presence of an anomaly in a living child--was 6.4 percent among the unrelated couples in the NRR, with one spouse born outside the area of current residence ("migrant"). Considering this as the base, the excess relative risks in the other groups are: "NRR-nonmigrant," 35 percent; "HBRR-nonmigrant," 69 percent; "NRR-consanguineous," 76 percent; and "NBRR-consanguineous," 157 percent. Ionizing radiation, consanguinity, and nearness of birthplace of the spouse are risk factors for the death of offspring and for anomalies. The higher risk among the "nonmigrant" couples may be due to geographic inbreeding. The findings are suggestive of an autosomal recessive etiology for the majority of the multifactorial anomalies.
Authors:
V T Padmanabhan; A P Sugunan; C K Brahmaputhran; K Nandini; K Pavithran
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of health services : planning, administration, evaluation     Volume:  34     ISSN:  0020-7314     ISO Abbreviation:  Int J Health Serv     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-06     Completed Date:  2004-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1305035     Medline TA:  Int J Health Serv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-515     Citation Subset:  IM    
Affiliation:
Green Audit, Aberystwyth, United Kingdom. vtpadma@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / epidemiology*,  etiology
Abnormalities, Radiation-Induced / epidemiology*
Adolescent
Adult
Cohort Studies
Consanguinity
Dose-Response Relationship, Radiation
Environmental Exposure / adverse effects*
Female
Fertility / radiation effects
Humans
India / epidemiology
Male
Mutation
Pregnancy
Pregnancy Outcome / epidemiology
Radiation, Ionizing
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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