Document Detail


Heritability of ventilatory function in smoking and nonsmoking New Mexico Hispanics.
MedLine Citation:
PMID:  1928947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Familial aggregation of ventilatory function has been described in several populations, but the effects of age and cigarette smoking on the extent of aggregation have not been well characterized. We used data from a survey of a Hispanic population in New Mexico to obtain estimates of heritability for FVC and FEV1 as percentages of predicted value. Product-moment correlations for FVC of spouse pairs were 0.18 (n = 90 pairs) if neither smoked, 0.013 (n = 45 pairs) if only the wife smoked, 0.18 (n = 118 pairs) if only the husband smoked, and -0.04 (n = 83 pairs) if both smoked. Correlations for FEV1 of spouse pairs were similar. Because parent-child correlations did not vary with sex, we calculated product-moment correlations from the pooled data. The parent-child correlations for nonsmoking parents with nonsmoking children 6 to 17 yr of age and living in the same house were 0.16 (n = 335 pairs) and 0.17 for FVC and FEV1, respectively. For parents whose children were 25 yr of age or older, the parent-child correlations for those living in different houses were 0.37 (n = 63 pairs) for FVC and 0.40 for FEV1 if neither smoked, and 0.24 (n = 27 pairs) for FVC and 0.14 for FEV1 if both smoked. Heritability estimates, estimated by path analysis, were 0.43 for FVC and 0.42 for FEV1 if neither family member smoked and 0.65 for FVC and 0.44 for FEV1 if both family members smoked. We conclude that there is a moderate degree of heritability of FVC and FEV1 with no substantial change based on age or smoking status.
Authors:
D B Coultas; C L Hanis; C A Howard; B J Skipper; J M Samet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  144     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-11-01     Completed Date:  1991-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  770-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, New Mexico Tumor Registry, University of New Mexico Medical Center, Albuquerque 87131.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Family Health / ethnology
Forced Expiratory Volume / genetics
Genotype
Hispanic Americans / genetics*,  statistics & numerical data
Humans
Models, Genetic
New Mexico / epidemiology
Respiration / genetics*
Sex Factors
Smoking / epidemiology,  genetics*,  physiopathology
Vital Capacity / genetics
Grant Support
ID/Acronym/Agency:
5-K04 HL-00951/HL/NHLBI NIH HHS; HL-28128/HL/NHLBI NIH HHS; N01-CN-55425/CN/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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