Document Detail

Heritability of parturition timing: an extended twin design analysis.
MedLine Citation:
PMID:  18295169     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to assess relative maternal and paternal genetic influences on birth timing. STUDY DESIGN: Utilizing The Netherlands Twin Registry, we examined the correlation in birth timing of infants born to monozygotic (MZ) twins and their first-degree relatives (dizygotic twins and siblings of twins). Genetic models estimated the relative influence of genetic and common environmental factors through model fitting of additive genetic (A), common environmental (C), individual-specific environmental factors, and combinations thereof. RESULTS: We evaluated birth timing correlation among the infants of 1390 twins and their 644 siblings. The correlation in MZ female twins (r = 0.330) was greater than MZ male twins (r = -0.096). Positive correlation were also found in sister-sister pairs (r = 0.223) but not in brother-brother (r = -0.045) or brother-sister pairs (r = -0.038). The most parsimonious AE model indicated a significant maternal contribution of genetic and individual-specific environmental factors to birth timing, but no paternal heritability was demonstrated. Heritability of birth timing in women was 34%; and the remaining variance (66%) was caused by individual-specific environmental factors. CONCLUSION: Our data implicate a significant contribution of maternal but not paternal genetic influences on birth timing.
Zachary A-F Kistka; Emily A DeFranco; Lannie Ligthart; Gonneke Willemsen; Jevon Plunkett; Louis J Muglia; Dorret I Boomsma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2008-03-04
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  199     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43.e1-5     Citation Subset:  AIM; IM    
Department of Pediatrics, Washington University, St Louis, MO, USA.
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MeSH Terms
Middle Aged
Parturition / genetics*
Sex Factors
Time Factors
Twins / genetics*
Twins, Dizygotic / genetics
Twins, Monozygotic / genetics

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