Document Detail

Heritability of parturition timing: an extended twin design analysis.
MedLine Citation:
PMID:  18295169     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to assess relative maternal and paternal genetic influences on birth timing. STUDY DESIGN: Utilizing The Netherlands Twin Registry, we examined the correlation in birth timing of infants born to monozygotic (MZ) twins and their first-degree relatives (dizygotic twins and siblings of twins). Genetic models estimated the relative influence of genetic and common environmental factors through model fitting of additive genetic (A), common environmental (C), individual-specific environmental factors, and combinations thereof. RESULTS: We evaluated birth timing correlation among the infants of 1390 twins and their 644 siblings. The correlation in MZ female twins (r = 0.330) was greater than MZ male twins (r = -0.096). Positive correlation were also found in sister-sister pairs (r = 0.223) but not in brother-brother (r = -0.045) or brother-sister pairs (r = -0.038). The most parsimonious AE model indicated a significant maternal contribution of genetic and individual-specific environmental factors to birth timing, but no paternal heritability was demonstrated. Heritability of birth timing in women was 34%; and the remaining variance (66%) was caused by individual-specific environmental factors. CONCLUSION: Our data implicate a significant contribution of maternal but not paternal genetic influences on birth timing.
Zachary A-F Kistka; Emily A DeFranco; Lannie Ligthart; Gonneke Willemsen; Jevon Plunkett; Louis J Muglia; Dorret I Boomsma
Related Documents :
16009639 - Birth order and delivery interval: analysis of twin pair perinatal outcomes.
3071069 - Fertility, fecundity and twinning: a comparison of the trends in births and twinning in...
11296149 - Placental abruption among singleton and twin births in the united states: risk factor p...
831499 - Lumbar epidural analgesia for labor and delivery of twins.
11332779 - Discordant and nondiscordant twins: comparative multimethod risk assessment in the neon...
6538639 - Increased deaths due to endocrine system diseases and allergies among mothers of dizygo...
15019539 - Lipoprotein concentrations in newborns are associated with allelic variations in their ...
6954939 - Effects of betel chewing on pregnancy outcome.
22954269 - Control of oxygenation during mechanical ventilation in the premature infant.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2008-03-04
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  199     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43.e1-5     Citation Subset:  AIM; IM    
Department of Pediatrics, Washington University, St Louis, MO, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Middle Aged
Parturition / genetics*
Sex Factors
Time Factors
Twins / genetics*
Twins, Dizygotic / genetics
Twins, Monozygotic / genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  First-trimester pregnancy-associated plasma protein A and subsequent abnormalities of fetal growth.
Next Document:  Plasma of pregnant and preeclamptic women activates monocytes in vitro.