Document Detail

Heritability and other determinants of left ventricular diastolic function in the family-based population study.
MedLine Citation:
PMID:  25004373     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Understanding to what extent genetic factors influence diastolic Doppler indexes is an important issue in view of the relation of left ventricular diastolic dysfunction with outcome. We, therefore, investigated the heritability of left ventricular diastolic traits and the composite diastolic score in nuclear families recruited from the general population.
METHODS:: In a random sample of 316 nuclear families (452 parents and 600 offspring, mean age, 58.5 and 33.3 years), we measured transmitral early and late diastolic velocities (E and A) by pulsed wave Doppler, and mitral annular velocities (e' and a') by tissue Doppler. Using principal component analysis, we summarized seven Doppler indexes - namely, E, A, e' and a' velocities, and their ratios - into a single diastolic score. To calculate the heritability of diastolic indexes, we used variance decomposition in nuclear families and offspring as implemented in SOLAR and SAS, and the regression slope of offspring on mid-parent residual values.
RESULTS:: In variance decomposition analyses in nuclear families, the abovementioned traits with adjustment for covariables had moderate heritability ranging from 0.27 to 0.43 (P < 0.0001 for all). The parent-offspring concordances of all diastolic indexes were significant and ranged from 0.17 for A (P = 0.009) to 0.42 for e' (P < 0.0001). In nuclear families and offspring, the heritability estimates of the composite diastolic score were 0.42 and 0.64, respectively (P < 0.0001).
CONCLUSION:: Our study demonstrated moderate heritability of various indexes reflecting left ventricular diastolic function in nuclear families. The observation highlights the necessity of further research into the genes that affect left ventricular diastolic function.
Malgorzata Kloch-Badelek; Judita Knez; Valérie Tikhonoff; Lutgarde Thijs; Wojciech Sakiewicz; Andrew Ryabikov; Katarzyna Stolarz-Skrzypek; Yu Jin; Sofia Malyutina; Edoardo Casiglia; Krzysztof Narkiewicz; Danuta Czarnecka; Kalina Kawecka-Jaszcz; Jan A Staessen; Tatiana Kuznetsova
Related Documents :
19761503 - Atrial tachycardia with atypical wenckebach atrioventricular block after slow pathway a...
25245713 - An apical left ventricular aneurysm rupture presenting as left breast mass 11 years aft...
4036983 - Adverse effects due to morphine sulfate. challenge to previous clinical doctrine.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-4
Journal Detail:
Title:  Journal of hypertension     Volume:  -     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular P...
Next Document:  Inhibition of very long acyl chains sphingolipid synthesis modifies membrane dynamics during plant c...