Document Detail

Heritability of morningness-eveningness and self-report sleep measures in a family-based sample of 521 hutterites.
MedLine Citation:
PMID:  16393707     Owner:  NLM     Status:  MEDLINE    
Individual variation in the phase and amplitude of human circadian rhythms is well known, but the impact of heritable factors on such variation is less clear. We estimated the narrow-sense heritability for selected circadian and sleep timing, quality, and duration measures among related members of the Hutterites, an endogamous, religious community (n=521 participants). "Morningness-eveningness" (M/E), a stable trait reflecting circadian phase, was evaluated using the Composite Scale (CS). Subjective sleep measures were assessed using the Sleep Timing Questionnaire. Initial analyses reconfirmed the impact of age on M/E. Previously reported correlations between M/E scores and the sleep measures were also noted, demonstrating the construct validity of the questionnaires among the participants. Following corrections for age, gender, and colony of residence, significant narrow-sense heritability was noted for M/E (23%). The heritability for subjective sleep measures (related to timing, duration, and quality) were statistically significant for all but one variable, and varied between 12.4% and 29.4%. Thus, significant heritable influences on human circadian phase and subjective sleep indices can be detected through family-based studies. In view of the impact of circadian malfunction on human health, it may be worthwhile to map genetic factors impacting circadian and sleep variation.
Lambertus Klei; Patrick Reitz; Mary Miller; Joel Wood; Selma Maendel; David Gross; Tony Waldner; Joseph Eaton; Timothy H Monk; Vishwajit L Nimgaonkar
Related Documents :
16120097 - The dim light melatonin onset following fixed and free sleep schedules.
16944677 - Circadian phase in delayed sleep phase syndrome: predictors and temporal stability acro...
6143647 - Pineal melatonin in hibernating and aroused golden hamsters (mesocricetus auratus).
2011617 - The influence of intravenous l-tryptophan on plasma melatonin and sleep in men.
19789587 - The effect of nd:yag laser posterior capsulotomy on ocular wave front aberrations.
19034137 - Bilateral corneal erosion due to retail purchase of unfitted prescription contact lense...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chronobiology international     Volume:  22     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2005  
Date Detail:
Created Date:  2006-01-05     Completed Date:  2006-04-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1041-54     Citation Subset:  IM    
Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Circadian Rhythm / physiology*
Ethnic Groups*
Germany / ethnology
Life Style
Sleep / physiology*
Wakefulness / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Morning versus evening power output and repeated-sprint ability.
Next Document:  Association between moringness-eveningness preference and mental/physical premenstrual symptoms in J...