Document Detail


Heritability of morningness-eveningness and self-report sleep measures in a family-based sample of 521 hutterites.
MedLine Citation:
PMID:  16393707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individual variation in the phase and amplitude of human circadian rhythms is well known, but the impact of heritable factors on such variation is less clear. We estimated the narrow-sense heritability for selected circadian and sleep timing, quality, and duration measures among related members of the Hutterites, an endogamous, religious community (n=521 participants). "Morningness-eveningness" (M/E), a stable trait reflecting circadian phase, was evaluated using the Composite Scale (CS). Subjective sleep measures were assessed using the Sleep Timing Questionnaire. Initial analyses reconfirmed the impact of age on M/E. Previously reported correlations between M/E scores and the sleep measures were also noted, demonstrating the construct validity of the questionnaires among the participants. Following corrections for age, gender, and colony of residence, significant narrow-sense heritability was noted for M/E (23%). The heritability for subjective sleep measures (related to timing, duration, and quality) were statistically significant for all but one variable, and varied between 12.4% and 29.4%. Thus, significant heritable influences on human circadian phase and subjective sleep indices can be detected through family-based studies. In view of the impact of circadian malfunction on human health, it may be worthwhile to map genetic factors impacting circadian and sleep variation.
Authors:
Lambertus Klei; Patrick Reitz; Mary Miller; Joel Wood; Selma Maendel; David Gross; Tony Waldner; Joseph Eaton; Timothy H Monk; Vishwajit L Nimgaonkar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chronobiology international     Volume:  22     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2005  
Date Detail:
Created Date:  2006-01-05     Completed Date:  2006-04-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1041-54     Citation Subset:  IM    
Affiliation:
Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Circadian Rhythm / physiology*
Ethnic Groups*
Female
Germany / ethnology
Humans
Life Style
Male
Pennsylvania
Questionnaires
Sleep / physiology*
Wakefulness / physiology
Grant Support
ID/Acronym/Agency:
AG13396/AG/NIA NIH HHS; MH56242/MH/NIMH NIH HHS; MH63420/MH/NIMH NIH HHS; MH66263/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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