| Heritability of left ventricular and papillary muscle heart size: a twin study with cardiac magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 19406865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Earlier studies in monozygotic (MZ) and dizygotic (DZ) twins showed genetic variance on echocardiographically determined heart size. However, cardiovascular magnetic resonance (CMR) is more precise and reproducible. We performed a twin study relying on CMR, focusing on left ventricular (LV) mass and papillary muscle, since there are no genetic reports on this structure. METHODS AND RESULTS: We measured left heart dimensions of 25 healthy twin pairs with a 1.5T MR scanner, analysed with the mass, Medis Software. We performed heritability analysis and tests for genetic influences shared between cardiac structures. We found that CMR-based heritability estimates (h(2) = 84%) substantially exceeded estimates based on echocardiography. We also found significant genetic influence on papillary muscle mass (h(2) = 82%). Bivariate analysis of papillary and LV muscle mass revealed significant genetic influences shared by both phenotypes (genetic correlation 0.59) and suggested an additional genetic component specific to papillary muscle. We observed correlations between body mass index, surface area, and systolic blood pressure with cardiac dimensions, even in this small study. Environmental influences were relevant as well, indicating reciprocal influences on papillary vs. LV muscle mass. CONCLUSION: Cardiovascular magnetic resonance, even with few subjects, allows a genetic assessment of cardiac structures that cannot be attained with echocardiography. Hitherto fore unappreciated relationships can be uncovered by this method. |
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Authors:
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Christoph A Busjahn; Jeanette Schulz-Menger; Hassan Abdel-Aty; Andre Rudolph; Jens Jordan; Friedrich C Luft; Andreas Busjahn |
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Publication Detail:
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Type: Journal Article; Twin Study Date: 2009-04-30 |
Journal Detail:
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Title: European heart journal Volume: 30 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-02 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 1643-7 Citation Subset: IM |
Affiliation:
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Medical Faculty of the Charité, Franz-Volhard Clinic, HELIOS Klinikum-Berlin, Experimental and Clinical Research Center and Max Delbrueck Center for Molecular Medicine, Berlin, Germany. busjahn@healthtwist.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / genetics Body Mass Index Female Heart / anatomy & histology* Heart Ventricles / anatomy & histology Humans Magnetic Resonance Imaging / methods Male Middle Aged Organ Size / genetics Papillary Muscles / anatomy & histology Twins, Dizygotic / genetics, physiology Twins, Monozygotic / genetics, physiology Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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