| Heritability of left ventricular mass in a large cohort of twins. | |
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MedLine Citation:
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PMID: 16508579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Left ventricular hypertrophy is recognized as one of the most important independent predictors of adverse cardiovascular outcome. The aetiology of LVH includes a number of well-recognized causes but there is considerable interest in the genetics of cardiac muscle hypertrophy. We used a large prospective twin database in order to establish the heritability of left ventricular mass (LVM). METHODS: Normotensive twins were prospectively recruited. Demographic data were collected. The LVM was determined using the Penn formulae derived from data collected from echocardiography. RESULTS: A total of 376 Caucasian twin pairs (182 monozygotic and 194 dizygotic) aged 25-79 years were recruited. All subjects were normotensive with no significant differences in blood pressure (mean blood pressure: monozygotic twins, 132/83 mmHg; dizygotic twins, 131/82 mmHg) or body mass index between the monozygotic and dizygotic twins. The mean LVM for monozygotic twins was 140.9 g, compared with 140.2 g for dizygotic twins. Heritability estimates suggest that the genetic variance of LVM is 0.59 (95% confidence interval, 0.5-0.67). No common shared environmental effects were identified under this model. CONCLUSION: Our data from the largest set of twin pairs studied to date show that LVM has a sizeable genetic basis that is probably polygenic. This result has important implications for the understanding of normal and abnormal cardiac morphology at the molecular level. |
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Authors:
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Pankaj Sharma; Rita P S Middelberg; Toby Andrew; Michael R Johnson; Howard Christley; Morris J Brown |
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Publication Detail:
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Type: Journal Article; Twin Study |
Journal Detail:
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Title: Journal of hypertension Volume: 24 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-03-01 Completed Date: 2006-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 321-4 Citation Subset: IM |
Affiliation:
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Department of Clinical Neuroscience, Hammersmith Hospitals & Imperial College, London, UK. psharma@imperial.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index Female Humans Hypertrophy, Left Ventricular / genetics* Male Middle Aged |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2006 Feb;24(2):273-7
[PMID:
16508570
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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