Document Detail

Heritability of left ventricular mass in a large cohort of twins.
MedLine Citation:
PMID:  16508579     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Left ventricular hypertrophy is recognized as one of the most important independent predictors of adverse cardiovascular outcome. The aetiology of LVH includes a number of well-recognized causes but there is considerable interest in the genetics of cardiac muscle hypertrophy. We used a large prospective twin database in order to establish the heritability of left ventricular mass (LVM). METHODS: Normotensive twins were prospectively recruited. Demographic data were collected. The LVM was determined using the Penn formulae derived from data collected from echocardiography. RESULTS: A total of 376 Caucasian twin pairs (182 monozygotic and 194 dizygotic) aged 25-79 years were recruited. All subjects were normotensive with no significant differences in blood pressure (mean blood pressure: monozygotic twins, 132/83 mmHg; dizygotic twins, 131/82 mmHg) or body mass index between the monozygotic and dizygotic twins. The mean LVM for monozygotic twins was 140.9 g, compared with 140.2 g for dizygotic twins. Heritability estimates suggest that the genetic variance of LVM is 0.59 (95% confidence interval, 0.5-0.67). No common shared environmental effects were identified under this model. CONCLUSION: Our data from the largest set of twin pairs studied to date show that LVM has a sizeable genetic basis that is probably polygenic. This result has important implications for the understanding of normal and abnormal cardiac morphology at the molecular level.
Pankaj Sharma; Rita P S Middelberg; Toby Andrew; Michael R Johnson; Howard Christley; Morris J Brown
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Publication Detail:
Type:  Journal Article; Twin Study    
Journal Detail:
Title:  Journal of hypertension     Volume:  24     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-01     Completed Date:  2006-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  IM    
Department of Clinical Neuroscience, Hammersmith Hospitals & Imperial College, London, UK.
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MeSH Terms
Body Mass Index
Hypertrophy, Left Ventricular / genetics*
Middle Aged
Comment In:
J Hypertens. 2006 Feb;24(2):273-7   [PMID:  16508570 ]

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