Document Detail


Heritability and genetic correlations of metabolic disease-related phenotypes in Mexico: preliminary report from the GEMM Family Study.
MedLine Citation:
PMID:  17985661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on disease, at 9 medical institutions across Mexico. Participants were measured for anthropometric (stature, weight, waist circumference) and hemodynamic (blood pressure, heart rate) phenotypes; glucose, cholesterol, and triglyceride levels were measured in fasting blood. Variance components-based quantitative genetic analyses were performed using SOLAR. All phenotypes except diastolic blood pressure were significantly heritable. Consistent with the definition of metabolic syndrome, many phenotypes exhibited significant environmental correlation, and significant genetic correlations were found between measures of adiposity and fasting glucose and fasting triglyceride levels. These preliminary data represent the first heritability estimates for many of these phenotypes in the Republic of Mexico and indicate that this study design offers excellent power for future gene discovery relative to metabolic disease.
Authors:
Raul A Bastarrachea; Jack W Kent; Guadalupe Rozada; Shelley A Cole; Juan C López-Alvarenga; Celia Aradillas; Olga Brito-Zurita; Ricardo M Cerda-Flores; Emma Ibarra-Costilla; Esther Gallegos; Hugo Laviada-Molina; Victor Hernandez-Escalante; Juan Rosas; Anselmo Machado; Felipe Vadillo; Manuel Ramos; Brissia Lazalde; Jesus Santa-Olalla; Jean W MacCluer; Anthony G Comuzzie
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human biology     Volume:  79     ISSN:  0018-7143     ISO Abbreviation:  Hum. Biol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-11-07     Completed Date:  2007-12-06     Revised Date:  2011-04-18    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-9     Citation Subset:  IM    
Affiliation:
Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anthropometry
Blood Pressure / genetics
Cardiovascular Diseases / epidemiology,  genetics*
Female
Genetics, Population / methods*
Humans
Male
Metabolic Syndrome X / epidemiology,  genetics*
Mexico / epidemiology
Middle Aged
Phenotype*
Grant Support
ID/Acronym/Agency:
C06-RR017515/RR/NCRR NIH HHS; MH59490/MH/NIMH NIH HHS; P01-HL45522/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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