Document Detail


Heritability estimates of body size in fetal life and early childhood.
MedLine Citation:
PMID:  22848364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins.
METHODS: This study was embedded in the Generation R Study (n = 3407, singletons) and the Netherlands Twin Register (n = 33694, twins). For the heritability estimates in Generation R, regression models as proposed by Galton were used. In the Twin Register we used genetic structural equation modelling. Parental height and weight were measured and fetal growth characteristics (femur length and estimated fetal weight) were measured by ultrasounds in 2(nd) and 3(rd) trimester (Generation R only). Height and weight were assessed at multiple time-points from birth to 36 months in both studies.
RESULTS: Heritability estimates for length increased from 2(nd) to 3(rd) trimester from 13% to 28%. At birth, heritability estimates for length in singletons and twins were both 26% and 27%, respectively, and at 36 months, the estimates for height were 63% and 72%, respectively. Heritability estimates for fetal weight increased from 2(nd) to 3(rd) trimester from 17% to 27%. For birth weight, heritability estimates were 26% in singletons and 29% in twins. At 36 months, the estimate for twins was 71% and higher than for singletons (42%).
CONCLUSIONS: Heritability estimates for height and weight increase from second trimester to infancy. This increase in heritability is observed in singletons and twins. Longer follow-up studies are needed to examine how the heritability develops in later childhood and puberty.
Authors:
Dennis O Mook-Kanamori; Catharina E M van Beijsterveldt; Eric A P Steegers; Yurii S Aulchenko; Hein Raat; Albert Hofman; Paul H Eilers; Dorret I Boomsma; Vincent W V Jaddoe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2012-07-25
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-31     Completed Date:  2013-04-02     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e39901     Citation Subset:  IM    
Affiliation:
The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Body Size / genetics*
Female
Femur / growth & development
Fetal Development / physiology*
Fetal Weight / genetics*
Fetus / physiology*
Humans
Infant, Newborn
Male
Netherlands
Pregnancy / physiology*
Pregnancy Trimester, Second / physiology
Pregnancy Trimester, Third / physiology
Registries*
Twins, Dizygotic
Twins, Monozygotic
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