Document Detail


Heritability of erythrocyte sodium permeability: a possible genetic marker for hypertension.
MedLine Citation:
PMID:  19667408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individuals genetically susceptible to hypertension may have preexisting membrane defects influencing cell sodium permeability. Fourteen Minnesotan families of Northern European descent were selected as having one or both progenitors with either high (HP) or low (LP) erythrocyte sodium permeability. We earlier found that over one-half of the (22)Na(+) influx into HP erythrocytes can be inhibited by micromolar amounts of furosemide, which has no apparent effect on LP erythrocytes. In these families, we find a significant midpoint parent/offspring correlation in the furosemide-sensitive component of erythrocyte (22)Na(+) flux rates (p <0.001). The relationship between parents and children in this metric trait is most consistent with a single locus, 2-allele system with variable expression, which suggests that enhanced furosemide-sensitive (22)Na(+) influx may be inherited as an autosomal recessive trait. Individuals with HP erythrocytes tend to have increased blood pressure and/or a family history of hypertension. The results were confirmed in these family samples with HP and LP (22)Na(+) influx (mmol/L RBC/hr): 0.404 +/- 0.03 vs 0.232 +/- 0.01 (p < 0.001); systolic blood pressure (mm Hg): 136 +/- 4 vs 108 +/- 4 (p < 0.001); and diastolic blood pressure (mm Hg): 89 +/- 2 vs 69 +/- 2 (p <0.001). These results may help to identify inherited factors involved in salt sensitive hypertension.
Authors:
Jong Y Lee; Ronald J Prineas; John W Eaton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  39     ISSN:  1550-8080     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-50     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Pressure / genetics
Cell Membrane Permeability / drug effects,  genetics*
Child
Dithiothreitol / pharmacology
Erythrocyte Membrane / drug effects,  metabolism*
Female
Furosemide / pharmacology
Genetic Markers / drug effects
Humans
Hypertension / genetics*
Male
Pedigree
Sodium / metabolism*
Grant Support
ID/Acronym/Agency:
R01 HL-19877/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 3483-12-3/Dithiothreitol; 54-31-9/Furosemide; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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