| Heritability of daytime ambulatory blood pressure in an extended twin design. | |
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MedLine Citation:
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PMID: 15557390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study estimated the genetic influences on ambulatory systolic and diastolic blood pressure, and on hypertensive status derived from ambulatory levels, in a family sample of 535 twins and 257 singleton siblings. This "extended twin design" was used to explicitly test the possibility that results obtained in singleton siblings are different from those obtained in twins. To examine the effects of excluding (medicated) hypertensive subjects, the genetic analyses were first performed under strict exclusion (medication and/or blood pressure >135/85 mm Hg), then without the medicated subjects, and, finally, without any exclusion. For the latter analysis, the untreated blood pressure values in subjects using antihypertensive medication were estimated by augmenting the observed blood pressure by the published efficacy of the specific antihypertensive medication used. No evidence was found for differential means, variances, or covariances of ambulatory blood pressure in singletons compared with twins. This indicates that estimates of heritability of ambulatory blood pressure from twin studies can be generalized to the singleton population. Heritability of hypertension, defined as a mean daytime blood pressure >135/85 mm Hg or antihypertensive medication use, was 61%. Genetic contribution to ambulatory blood pressure was highest when all subjects were included (systolic, 44% to 57%; diastolic, 46% to 63%) and lowest under strict exclusion (systolic, 32% to 50%; diastolic, 31% to 55%). We conclude that exclusion of (medicated) hypertensives removes part of the true genetic variance in ambulatory blood pressure. |
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Authors:
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Nina Kupper; Gonneke Willemsen; Harriëtte Riese; Daniëlle Posthuma; Dorret I Boomsma; Eco J C de Geus |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2004-11-22 |
Journal Detail:
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Title: Hypertension Volume: 45 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-31 Completed Date: 2005-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 80-5 Citation Subset: IM |
Affiliation:
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Department of Biological Psychology, Vrije Universiteit, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. hm.kupper@psy.vu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / pharmacology, therapeutic use Blood Pressure / drug effects, genetics* Blood Pressure Monitoring, Ambulatory Circadian Rhythm Diastole Female Humans Hypertension / drug therapy, genetics, physiopathology Male Multifactorial Inheritance Multivariate Analysis Netherlands / epidemiology Research Design Siblings Systole Twins, Dizygotic Twins, Monozygotic |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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