Document Detail

Heritability of daytime ambulatory blood pressure in an extended twin design.
MedLine Citation:
PMID:  15557390     Owner:  NLM     Status:  MEDLINE    
The present study estimated the genetic influences on ambulatory systolic and diastolic blood pressure, and on hypertensive status derived from ambulatory levels, in a family sample of 535 twins and 257 singleton siblings. This "extended twin design" was used to explicitly test the possibility that results obtained in singleton siblings are different from those obtained in twins. To examine the effects of excluding (medicated) hypertensive subjects, the genetic analyses were first performed under strict exclusion (medication and/or blood pressure >135/85 mm Hg), then without the medicated subjects, and, finally, without any exclusion. For the latter analysis, the untreated blood pressure values in subjects using antihypertensive medication were estimated by augmenting the observed blood pressure by the published efficacy of the specific antihypertensive medication used. No evidence was found for differential means, variances, or covariances of ambulatory blood pressure in singletons compared with twins. This indicates that estimates of heritability of ambulatory blood pressure from twin studies can be generalized to the singleton population. Heritability of hypertension, defined as a mean daytime blood pressure >135/85 mm Hg or antihypertensive medication use, was 61%. Genetic contribution to ambulatory blood pressure was highest when all subjects were included (systolic, 44% to 57%; diastolic, 46% to 63%) and lowest under strict exclusion (systolic, 32% to 50%; diastolic, 31% to 55%). We conclude that exclusion of (medicated) hypertensives removes part of the true genetic variance in ambulatory blood pressure.
Nina Kupper; Gonneke Willemsen; Harriëtte Riese; Daniëlle Posthuma; Dorret I Boomsma; Eco J C de Geus
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2004-11-22
Journal Detail:
Title:  Hypertension     Volume:  45     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-31     Completed Date:  2005-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  IM    
Department of Biological Psychology, Vrije Universiteit, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
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MeSH Terms
Antihypertensive Agents / pharmacology,  therapeutic use
Blood Pressure / drug effects,  genetics*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm
Hypertension / drug therapy,  genetics,  physiopathology
Multifactorial Inheritance
Multivariate Analysis
Netherlands / epidemiology
Research Design
Twins, Dizygotic
Twins, Monozygotic
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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