Document Detail


Heritability of angiotensin-converting enzyme and angiotensinogen: A comparison of US blacks and Nigerians.
MedLine Citation:
PMID:  10818078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensinogen (AGT) and angiotensin I-converting enzyme (ACE) are heritable traits, but whether the environmental context influences heritability has not been examined. Known genetic factors explain only a portion of variation in AGT and ACE, and levels of both proteins are influenced by the environment. The African diaspora provides an opportunity to compare these traits in genetically related populations in contrasting environments. As part of a study of the genetics of hypertension, we examined families that included 1449 Nigerians and 1147 African Americans. Body mass index (weight [kg]/height [m](2)) was 21 kg/m(2) in Nigeria and 29 kg/m(2) in the United States, which is consistent with a large environmental contrast. AGT was considerably higher among African Americans (1919 versus 1396, P<0.01), whereas ACE was higher in Nigerians (630 versus 517, P<0.01). A household effect was observed among the Nigerian families (spouse correlations 0.30 for AGT, 0.18 for ACE), and correlations among first-degree relatives were large (0.42 to 0. 51 and 0.36 to 0.38 for AGT and ACE, respectively). Among African Americans, the familial aggregations of AGT and ACE were very limited, and the familial correlation for AGT was not different from zero. Heritability was 77% for AGT and 67% for ACE in Nigeria and 18% for AGT and ACE in the United States. The familial patterns of body mass index and blood pressure were similar among both family sets. In conclusion, less familial aggregation was observed for AGT and ACE in the United States than in Nigeria, most likely reflecting a greater random individual environmental effect on these traits. Variation in heritability of traits could influence the power of epidemiological studies to identify genetic effects.
Authors:
R S Cooper; X Guo; C N Rotimi; A Luke; R Ward; A Adeyemo; S M Danilov
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  35     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1141-7     Citation Subset:  IM    
Affiliation:
Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA. rcooper@luc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group*
Angiotensinogen / genetics*
Female
Genetic Predisposition to Disease
Humans
Hypertension / ethnology,  genetics*
Male
Middle Aged
Nigeria / epidemiology
Peptidyl-Dipeptidase A / genetics*
United States / epidemiology
Grant Support
ID/Acronym/Agency:
HL-47910/HL/NHLBI NIH HHS; P41-RR-03655/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
11002-13-4/Angiotensinogen; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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