Document Detail


Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans.
MedLine Citation:
PMID:  15180698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous studies have demonstrated that increased C-reactive protein (CRP) levels predict coronary heart disease, stroke, peripheral vascular disease, and diabetes, and are associated with features of the metabolic syndrome. Only three previous studies have investigated the heritability of CRP levels, primarily in samples of Caucasian families. The purpose of the present study was to estimate the magnitude of genetic influences on CRP levels, and to examine potential associations between variation in the APOE gene and CRP levels, using a sample of 562 individual Japanese Americans from 68 extended kindreds. In general, correlation coefficients between first-degree relatives for CRP were approximately 0.2, and spouse correlations did not differ from zero, consistent with genetic influences. Heritability estimates were approximately 0.3 (p < 0.01), even with adjustment for factors known to influence CRP levels. A significant relationship was seen between unadjusted CRP levels and APOE genotypes (p = 0.02), with the highest mean CRP level among epsilon2 carriers (1.20 mg/L), and nearly the same mean levels among epsilon3/epsilon3 subjects and epsilon4 carriers (0.72 and 0.74 mg/L, respectively). However, this relationship was diminished with adjustment for covariates (p = 0.07). These results demonstrate the presence of both genetic and environmental effects on CRP levels among Asian Americans, and additional studies are needed to determine if the APOE gene contributes to these genetic influences.
Authors:
M A Austin; C Zhang; S E Humphries; W L Chandler; P J Talmud; K L Edwards; D L Leonetti; M J McNeely; W Y Fujimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of human genetics     Volume:  68     ISSN:  0003-4800     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-07     Completed Date:  2004-09-16     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  179-88     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, School of Public Health and Community Medicine, Box 357236, University of Washington, Seattle, WA 98195-7236, USA. maustin@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apolipoproteins E / genetics*
Asian Americans / genetics
C-Reactive Protein / genetics*,  metabolism
Female
Gene Frequency
Genetics, Population
Genotype
Humans
Male
Middle Aged
Pedigree
Grant Support
ID/Acronym/Agency:
DK-17047/DK/NIDDK NIH HHS; DK-31170/DK/NIDDK NIH HHS; HL-49293/HL/NHLBI NIH HHS; HL-50268/HL/NHLBI NIH HHS; HL-66682/HL/NHLBI NIH HHS; M01-RR00037/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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