| Heritability of arterial function, fitness, and physical activity in youth: a study of monozygotic and dizygotic twins. | |
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MedLine Citation:
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PMID: 20638076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To examine the role of heredity in determining flow-mediated dilation in young people by comparing conduit artery endothelial function in monozygotic and dizygotic twins. We also determined relationships between physical activity and fitness in each twin subset. STUDY DESIGN: Flow-mediated dilation was assessed with high-resolution ultrasonography of the brachial artery in 22 twin pairs (11 monozygotic pairs 13.3 ± 1.6 years, 11 dizygotic pairs 13.6 ± 1.6 years). Fitness was assessed as peak oxygen uptake during an incremental treadmill test. Physical activity was measured with accelerometry. Twin versus twin intraclass correlations were performed for both groups. RESULTS: Flow-mediated dilation was significantly correlated in monozygotic twins only (r = 0.60, P = .02). Heritability of flow-mediated dilation was estimated at 0.44. Total PA time (monozygotic r = 0.77, dizygotic r = 0.60, P < .05) and light physical activity time (monozygotic r = 0.67, dizygotic r = 0.63, P < .05) correlated significantly in both groups. The peak oxygen uptake (r = 0.84, P < .01) was correlated only in monozygotic twins. CONCLUSION: Genetic factors appear to be responsible for a modest portion of the flow-mediated dilation response, suggesting that flow-mediated dilation can be influenced by environmental factors. |
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Authors:
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Nicola Hopkins; Gareth Stratton; Jose Maia; Toni M Tinken; Lee E Graves; Tim N Cable; Daniel J Green |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2010-07-16 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 157 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-22 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 943-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Research Institute for Sport and Exercise Science, Liverpool John Moore's University, Liverpool, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arteries / physiology* Cross-Sectional Studies Endothelium, Vascular / physiology* Female Humans Male Motor Activity / genetics* Physical Fitness* Twins, Dizygotic* Twins, Monozygotic* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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