| Heritability of apnea of prematurity: a retrospective twin study. | |
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MedLine Citation:
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PMID: 20837586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Apnea of prematurity (AOP) is a disturbance in respiratory rhythm defined by idiopathic pauses in breathing that reduce blood oxygen levels and/or heart rate. It is a major clinical problem among preterm infants. OBJECTIVES: The primary goal of this study was to estimate the genetic susceptibility to AOP in a cohort of preterm twins. A secondary aim was to identify risk factors associated with AOP in this cohort. METHODS: A single-center, retrospective study (2000-2008) was performed by using data from 317 premature twin pairs (<36 weeks' gestational age). Heritability estimates were determined by comparing intrapair AOP concordance between 56 monozygotic and 161 dizygotic twin pairs by using structural equation modeling. Risk factors of AOP among a cohort of 543 premature twins were assessed by using mixed-effects logistic regression. RESULTS: The heritability of AOP was 87% (95% confidence interval [CI]: 0.64-0.97) among same-gender twins. A gender-dependent model revealed that genetic factors accounted for 99% of the variance in male twins (95% CI: 0.89-1.00) and 78% of the variance in female twins (95% CI: 0.49-0.94). Significant risk factors for AOP were low gestational age (P<.001), cesarean delivery (P=.017), and conception through assisted reproductive technologies (P=.008). CONCLUSIONS: These findings suggest that AOP has an important genetic basis underlying this developmental-related disorder of respiratory control. Future genomic studies may provide information on pathophysiological mechanisms that underlie AOP. |
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Authors:
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Elisabeth Bloch-Salisbury; Mei Hua Hall; Priya Sharma; Theonia Boyd; Francis Bednarek; David Paydarfar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2010-09-13 |
Journal Detail:
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Title: Pediatrics Volume: 126 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e779-87 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA. elisabeth.salisbury@umassmed.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apnea
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etiology,
genetics* Diseases in Twins / etiology, genetics* Female Genetic Predisposition to Disease Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / etiology, genetics* Male Risk Factors Twins, Dizygotic Twins, Monozygotic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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