Document Detail

The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique.
MedLine Citation:
PMID:  9516215     Owner:  NLM     Status:  MEDLINE    
Both end-inspiratory (EIO) and end-expiratory (EEO) occlusions have been used to measure the strength of the Hering-Breuer inflation reflex (HBIR) in infants. The purpose of this study was to compare both techniques in anesthetized infants. In each infant, HBIR activity was calculated as the relative prolongation of expiratory and inspiratory time during EIO and EEO, respectively. Respiratory drive was assessed from the change in airway pressure during inspiratory effort against the occlusion, both at a fixed time interval of 100 ms (P0.1) and a fixed proportion (10%) of the occluded inspiratory time (P10%). Twenty-two infants [age 14.3 +/- 6. 4 (SD) mo] were studied. No HBIR activity was present during EIO [-11.8 +/- 15.9 (SD) %]. By contrast, there was significant, albeit weak, reflex activity during EEO [HBIR: 27.2 +/- 17.4%]. A strong HBIR (up to 310%) was elicited in six of seven infants in whom EIO was repeated after lung inflation. P0.1 was similar during both types of occlusions, whereas mean +/- SD P10% was lower during EEO than during EIO: 0.198 +/- 0.09 vs. 0.367 +/- 0.15 kPa, respectively (P < 0.01). These data suggest a difference in the central integration of stretch receptor activity in infants during anesthesia compared with during sleep.
K Brown; J Stocks; C Aun; P S Rabbette
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  84     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-05     Completed Date:  1998-05-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1437-46     Citation Subset:  IM    
Department of Anaesthesia, Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3.
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MeSH Terms
Anesthesia, Inhalation*
Anesthetics, Inhalation*
Double-Blind Method
Forced Expiratory Flow Rates
Lung / physiology
Lung Volume Measurements
Methyl Ethers*
Reflex / physiology*
Respiration, Artificial
Respiratory Function Tests / methods*
Respiratory Mechanics / physiology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 151-67-7/Halothane; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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