Document Detail

Heredity of food allergies in an unselected child population: An epidemiological survey from Finland.
MedLine Citation:
PMID:  20961338     Owner:  NLM     Status:  In-Data-Review    
To cite this article:Pyrhönen K, Hiltunen L, Kaila M, Näyhä S, Läärä E. Heredity of food allergies in an unselected child population: An epidemiological survey from Finland.Pediatr Allergy Immunol 2011; 22: e124-e132. ABSTRACT: The heredity of food allergies (FA) has not previously been addressed in a large unselected child population. Our target population comprised all children born from April 2001 to March 2006 resident in one province of South-East Finland (n c. 6000), as identified from the national population register. In a questionnaire survey conducted in 2005-2006, data were obtained on allergic manifestations (FA symptoms, atopic rash, allergic asthma, hay fever/pollen allergy, or animal allergy) in the biologic parents of 3800 children (64% of the total). Concurrently with the survey but independently of it, results of specific immunoglobulin E antibodies (sIgE), skin prick tests (SPT), and open food challenges (OFC) in the offspring were collected from patient records throughout the province. Up to the age of 4 yr, the incidences of any positive FA test, a positive SPT or sIgE for food items, and a positive OFC in these children were threefold higher if both parents reported having an allergic manifestation and twofold higher if either mother or father had such a manifestation when compared with children whose parents did not report any of these conditions. The estimated risk of any positive FA test increased by a factor of 1.3 (95% CI 1.2-1.4) for each additional allergic manifestation in the parents. Positive FA tests in the offspring were relatively strongly associated with the reports of allergic phenotypes and the number of these phenotypes in their biologic parents.
Kaisa Pyrhönen; Liisa Hiltunen; Minna Kaila; Simo Näyhä; Esa Läärä
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Publication Detail:
Type:  Journal Article     Date:  2010-10-20
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  22     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  e124-32     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
South Karelia District of Social and Health Services, Lappeenranta, Finland Unit of General Practice, Oulu University Hospital, Oulu, Finland Institute of Health Sciences, University of Oulu, Oulu, Finland Health Centre of Oulu, Oulu, Finland Paediatric Research Centre, Tampere University Hospital and University of Tampere, Tampere, Finland Finnish Institute of Occupational Health, Oulu, Finland Department of Mathematical Sciences, University of Oulu, Oulu, Finland.
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