Document Detail

Hereditary thrombophilic risk factors for recurrent pregnancy loss.
MedLine Citation:
PMID:  22460204     Owner:  NLM     Status:  In-Data-Review    
This review summarizes current knowledge about the role of hereditary hypercoagulation factors predisposing to thrombophilia-associated recurrent fetal loss. Thrombophilias are a major cause of adverse pregnancy outcome, playing a role in the etiology of up to 40% of cases worldwide. Hereditary thrombophilic predispositions to recurrent pregnancy wastage include genetic lesions in blood coagulation factors II and V as well as natural anticoagulants antithrombin, protein C, and protein S. Furthermore, methylenetetrahydrofolate reductase gene variants conferring higher thrombophilia risk in combination with these mutations and the newly described annexin A5 gene M2 promoter allele are associated with repeated fetal loss. The review gives a concise description of the molecular defects arising from the genetic changes, of the role these factors play in the timing and definition of fetal loss, and risk estimates from available studies and meta-analysis. This knowledge is instrumental for a more precise assessment of individual risks for repeated fetal loss and should guide therapeutic strategies, where relevant. Since the average childbearing age increases in Western societies, the importance of a timely diagnosis of fetal loss predisposition is increasing.
Nadja Bogdanova; Arseni Markoff
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Publication Detail:
Type:  Journal Article     Date:  2010-06-11
Journal Detail:
Title:  Journal of community genetics     Volume:  1     ISSN:  1868-6001     ISO Abbreviation:  J Community Genet     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2012-03-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101551501     Medline TA:  J Community Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  -    
Institute of Human Genetics, Westfalian-Wilhelms University of Muenster, Vesaliusweg 12-14, 48149, Münster, Germany,
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