Document Detail

Hereditary thrombophilia and recurrence of ischemic placental disease.
MedLine Citation:
PMID:  19782960     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth. STUDY DESIGN: Between 2001 and 2005, 110 consecutive women were included in the study and received 100 mg of aspirin daily. Adjustment was made for several maternal confounding factors using a logistic regression model. RESULTS: After multivariable logistic regression analyses, only abnormal UAD assessment was significantly associated with recurrent complications (odds ratio, 11.2; 95% confidence interval, 3.8-32.6) Combining the results of UAD and the presence of laboratory markers of thrombophilia failed to improve the accuracy of UAD to predict recurrent complications. CONCLUSION: Hereditary thrombophilia testing is not useful in predicting recurrent complications in subsequent pregnancy.
Eric Verspyck; Jeanne-Yvonne Borg; Horace Roman; Bernard Thobois; Patrick Pia; Lo?c Marpeau
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-09-26
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  202     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-25     Completed Date:  2010-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54.e1-5     Citation Subset:  AIM; IM    
Copyright Information:
2010 Mosby, Inc.
Department of Obstetrics and Gynecology, Rouen University Hospital, France.
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MeSH Terms
Abruptio Placentae / epidemiology*
Gestational Age
Logistic Models
Pre-Eclampsia / epidemiology*
Pregnancy Outcome*
Prospective Studies
ROC Curve
Stillbirth / epidemiology*
Thrombophilia / congenital*,  epidemiology*
Ultrasonography, Doppler
Uterus / blood supply

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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