| Hereditary neuroendocrine tumors of the gastroenteropancreatic system. | |
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MedLine Citation:
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PMID: 17684762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Approximately 5-10% of neuroendocrine tumors (NETs) of the gastroenteropancreatic system (GEP) have a hereditary background. The known inherited syndromes include multiple endocrine neoplasia type 1, neurofibromatosis type 1, von Hippel-Lindau disease, and the tuberous sclerosis complex. This review discusses for each of these syndromes the: (1) involved genes and specific types of mutations, (2) disease prevalence and penetrance, (3) affected neuroendocrine tissues and related clinical syndromes, (4) special morphological features of NETs and their putative precursor lesions. In addition, GEP-NETs clustering in individual families or associated with other malignancies without known genetic background are discussed. |
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Authors:
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Martin Anlauf; Nele Garbrecht; Juliane Bauersfeld; Anja Schmitt; Tobias Henopp; Paul Komminoth; Philipp U Heitz; Aurel Perren; Günter Klöppel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-08-08 |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 451 Suppl 1 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-20 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: Germany |
Other Details:
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Languages: eng Pagination: S29-38 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Kiel, Michaelisstr. 11, 24105, Kiel, Germany. manlauf@path.uni-kiel.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Digestive System Neoplasms
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genetics*,
pathology Genetic Predisposition to Disease* Humans Neuroendocrine Tumors / genetics*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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