Document Detail


Hereditary hemorrhagic telangiectasia, factor V Leiden and antiphospholipid syndrome: a case report.
MedLine Citation:
PMID:  11994568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report on a 57-year-old woman with three episodes of ischemic strokes and hereditary hemorrhagic telangiectasia (HHT). Tests for inherited and acquired thrombophilia showed elevated anticardiolipin immunoglobulin (Ig)M antibodies (on three separate occasions), anti-prothrombin IgG antibodies, and the heterozygous form of factor V Leiden. This is the first case of HHT, a primary antiphospholipid syndrome, combined with factor V Leiden. No detectable arteriovenous malformation was found and ischemic episodes, documented by computer tomography, were related to the presence of antiphospholipid antibodies and possibly the carriership of factor V Leiden mutation. Since aspirin provoked severe nasal hemorrhages, treatment with ticlopidine was initiated after the third stroke. Over an 18-month follow-up, ischemic episodes were absent and we regarded oral anticoagulation as unjustifiable.
Authors:
A Undas; S Bazan-Socha; J Swadzba; J Musial
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  13     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-05-08     Completed Date:  2002-11-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Anticardiolipin / blood
Antiphospholipid Syndrome / complications*,  immunology
Autoantibodies / blood
Factor V*
Female
Humans
Ischemia / etiology
Middle Aged
Pedigree
Platelet Aggregation Inhibitors / administration & dosage
Prothrombin / immunology
Stroke / etiology
Telangiectasia, Hereditary Hemorrhagic / complications*
Thrombophilia / complications*,  genetics
Ticlopidine / administration & dosage
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Autoantibodies; 0/Platelet Aggregation Inhibitors; 0/factor V Leiden; 55142-85-3/Ticlopidine; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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