| Hereditary hemorrhagic telangiectasia, factor V Leiden and antiphospholipid syndrome: a case report. | |
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MedLine Citation:
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PMID: 11994568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on a 57-year-old woman with three episodes of ischemic strokes and hereditary hemorrhagic telangiectasia (HHT). Tests for inherited and acquired thrombophilia showed elevated anticardiolipin immunoglobulin (Ig)M antibodies (on three separate occasions), anti-prothrombin IgG antibodies, and the heterozygous form of factor V Leiden. This is the first case of HHT, a primary antiphospholipid syndrome, combined with factor V Leiden. No detectable arteriovenous malformation was found and ischemic episodes, documented by computer tomography, were related to the presence of antiphospholipid antibodies and possibly the carriership of factor V Leiden mutation. Since aspirin provoked severe nasal hemorrhages, treatment with ticlopidine was initiated after the third stroke. Over an 18-month follow-up, ischemic episodes were absent and we regarded oral anticoagulation as unjustifiable. |
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Authors:
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A Undas; S Bazan-Socha; J Swadzba; J Musial |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 13 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-05-08 Completed Date: 2002-11-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 53-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Anticardiolipin
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blood Antiphospholipid Syndrome / complications*, immunology Autoantibodies / blood Factor V* Female Humans Ischemia / etiology Middle Aged Pedigree Platelet Aggregation Inhibitors / administration & dosage Prothrombin / immunology Stroke / etiology Telangiectasia, Hereditary Hemorrhagic / complications* Thrombophilia / complications*, genetics Ticlopidine / administration & dosage Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin; 0/Autoantibodies; 0/Platelet Aggregation Inhibitors; 0/factor V Leiden; 55142-85-3/Ticlopidine; 9001-24-5/Factor V; 9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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