| Hereditary haemochromatosis is unlikely to cause movement disorders--a critical review. | |
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MedLine Citation:
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PMID: 15258788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hereditary haemochromatosis (HH) is a common autosomal recessive systemic iron overload disorder in which CNS manifestations, particularly movement disorders, have been reported. We report a 63-year-old woman with familial HH with a four-year history of progressive gait disturbance, chorea, and mild cervical and laryngeal dystonia. Her movement disorder was thought to be related to the haemochromatosis. On further investigation, analysis for the Huntington's disease expansion was positive. A review of the seven published cases of movement disorders associated with HH as well as data concerning brain iron deposition in this condition leads us to debate the causal link between movement disorders and HH. We suggest that movement disorders are rare in association with HH, and that such patients should be thoroughly investigated for another cause for their movement disorder. |
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Authors:
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Noemi Russo; Mark Edwards; Thomasin Andrews; Michael O'Brien; Kailash P Bhatia |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of neurology Volume: 251 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-19 Completed Date: 2004-10-20 Revised Date: 2007-07-10 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 849-52 Citation Subset: IM |
Affiliation:
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Sobell Department of Motor Neuroscience & Movement Disorders, Institute of Neurology, University College London, Queen Square, WC1N 3BG, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Basal Ganglia
/
metabolism,
pathology,
physiopathology* Diagnosis, Differential Disease Progression Family Health Female Hemochromatosis / complications, diagnosis* Hepatic Encephalopathy / diagnosis, physiopathology Humans Huntington Disease / complications, diagnosis*, genetics* Iron / metabolism, toxicity Middle Aged Movement Disorders / diagnosis*, etiology, genetics Trinucleotide Repeat Expansion / genetics |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
| Comments/Corrections | |
Comment In:
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J Neurol. 2007 Jan;254(1):113-4
[PMID:
17508145
]
J Neurol. 2006 Feb;253(2):261-2 [PMID: 16096812 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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