Document Detail

Hereditary gingival hyperplasia associated with amelogenesis imperfecta: A case report.
MedLine Citation:
PMID:  22532955     Owner:  NLM     Status:  In-Data-Review    
Hereditary gingival fibromatosis (HGF) and amelogenesis imperfecta (AI) are two rare oral conditions with genetic etiologies. The case of a 17-year-old boy affected by HGF, AI, anterior open bite, and pyramidal impaction of the maxillary molars is reported. Internal bevel gingivectomies were carried out to reduce gingival overgrowth. Clinical examination of the family revealed the presence of HGF and AI in his 12-year-old sister (both in milder forms) and of HGF in his older half brother. Genetic sequencing analyses were performed to detect any of the known mutations leading to HGF and AI. Histologic analysis revealed the presence of fibroepithelial hyperplasia, consistent with a diagnosis of GF. Sequencing genetic analysis failed to identify any of the common mutations leading to HGF (SOS-1) or AI (enamelin and amelogenin genes). This phenotype, similar to what has been described in other families, may represent a new syndrome caused by an as-yet unknown genotype. (Quintessence Int 2012;43:483-489).
Luigi Nibali; Peter M Brett; Nikos Donos; Gareth S Griffiths
Related Documents :
16410965 - Genetic diversity of triatoma infestans (hemiptera: reduviidae) in chuquisaca, bolivia ...
19076275 - Genetic diversity and gene flow in collapsed and healthy abalone fisheries.
22801565 - Clinical case seminar. peculiar prolactinomas in patients with pituitary developmental ...
18302685 - Historical fragmentation of islands and genetic drift in populations of galápagos lava...
17248745 - Controlling elements in a tribal maize from colombia: fcu , a two-unit system.
14755725 - Clinical features of cerebral cavernous malformations patients with krit1 mutations.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Quintessence international (Berlin, Germany : 1985)     Volume:  43     ISSN:  1936-7163     ISO Abbreviation:  Quintessence Int     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342677     Medline TA:  Quintessence Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  D    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sinus augmentation with intra- vs extraorally harvested bone grafts for the provision of dental impl...
Next Document:  Bacterial and inflammatory behavior of implants in the early healing phase of chronic periodontitis.