Document Detail


Hereditary genodermatoses with cancer predisposition.
MedLine Citation:
PMID:  20816579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this article hereditary genodermatoses with cancer predisposition are reviewed, including nevoid basal cell carcinoma syndrome, neurofibromatosis types 1 and 2, tuberous sclerosis complex, xeroderma pigmentosum, and dyskeratosis congenita. Hereditary melanoma is also included, though it differs from the others in several respects. The underlying genetic aberrations causing these syndromes are largely known, allowing novel treatments to be developed for some of these disorders. Early recognition and diagnosis allows for close follow-up and surveillance for associated malignancies.
Authors:
Meg R Gerstenblith; Alisa M Goldstein; Margaret A Tucker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Hematology/oncology clinics of North America     Volume:  24     ISSN:  1558-1977     ISO Abbreviation:  Hematol. Oncol. Clin. North Am.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2011-01-21     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8709473     Medline TA:  Hematol Oncol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  885-906     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7236, USA. gerstenblithm@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Basal Cell Nevus Syndrome / genetics,  therapy
Genetic Predisposition to Disease*
Genetic Testing
Humans
Melanoma / genetics,  therapy
Neoplastic Syndromes, Hereditary / genetics*,  therapy
Neurofibromatoses / genetics,  therapy
Skin Diseases / genetics*,  therapy
Xeroderma Pigmentosum / genetics,  therapy
Grant Support
ID/Acronym/Agency:
Z01 CP004410-31/CP/NCI NIH HHS
Comments/Corrections

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