Document Detail


Hereditary evaluation of multiple developmental abnormalities in the Havanese dog breed.
MedLine Citation:
PMID:  17621585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Havanese is a toy breed that presents with a wide range of developmental abnormalities. Skeletal defects, particularly osteochondrodysplasia (OCD), are the most frequently observed anomalies. Cataracts, liver shunts, heart murmurs, and missing incisors are also common in this breed. Estimates of heritability and complex segregation analyses were carried out to evaluate modes of transmission for these abnormalities. A moderate heritability was identified and evidence for a single major locus was found. Novel statistical analysis methods were used to identify four traits that co-segregate: cataracts, hepatic abnormalities, OCD, and cardiac abnormalities. A canine-specific microarray was used to identify changes in gene expression in the liver that accompany the aforementioned developmental problems. One hundred and thirteen genes were found to be differentially regulated in the Havanese.
Authors:
Alison N Starr; Thomas R Famula; Nathan J Markward; Joanne V Baldwin; Karon D Fowler; Diane E Klumb; Nancy L Simpson; Keith E Murphy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-09
Journal Detail:
Title:  The Journal of heredity     Volume:  98     ISSN:  0022-1503     ISO Abbreviation:  J. Hered.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375373     Medline TA:  J Hered     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-7     Citation Subset:  IM    
Affiliation:
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4467, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / genetics
Animals
Chromosome Mapping
Congenital Abnormalities / genetics,  veterinary*
Dog Diseases / genetics*
Dogs
Gene Expression
Oligonucleotide Array Sequence Analysis
Phenotype

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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