| Hereditary colon cancer: lynch syndrome. | |
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MedLine Citation:
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PMID: 20559516 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome. |
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Authors:
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Eunjeong Jang; Daniel C Chung |
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Publication Detail:
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Type: Journal Article Date: 2010-06-16 |
Journal Detail:
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Title: Gut and liver Volume: 4 ISSN: 1976-2283 ISO Abbreviation: Gut Liver Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316452 Medline TA: Gut Liver Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 151-60 Citation Subset: - |
Affiliation:
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Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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