Document Detail

Hereditary breast ovarian cancer syndromes in the Maritimes.
MedLine Citation:
PMID:  20181317     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to characterize the population referred to the Maritime Medical Genetics Service (MMGS) because of increased risk of breast and/or ovarian cancer, and to evaluate the MMGS referral criteria for this population. METHODS: We reviewed a retrospective cohort of patients at increased risk of breast and/or ovarian cancer (n = 574) with appointments between January 2001 and May 2007 at the MMGS. Data analysis was performed using descriptive statistics in Filemaker Pro 8.5v1 and Microsoft Excel. RESULTS: Among 574 patients, 253 (44%) had test results available at the time of data collection, and 65 (25.7%) had BRCA mutations (44 BRCA1 and 21 BRCA2). Positive test results for each referral criterion ranged from 0% to 100%. CONCLUSION: Use of referral criteria at the MMGS yielded higher rates of positive test results than previously thought. It may be beneficial to expand testing criteria to ensure that everyone who may carry a mutation is offered testing.
Candace O'Quinn; Patricia Steele; Mark D Ludman; Katharina Kieser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obst?trique et gyn?cologie du Canada : JOGC     Volume:  32     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-25     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Faculty of Medicine, Dalhousie University, Halifax, NS.
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MeSH Terms
Breast Neoplasms / epidemiology,  genetics*
Cohort Studies
Genes, BRCA1
Genes, BRCA2
Genetic Testing*
Middle Aged
Ovarian Neoplasms / epidemiology,  genetics*
Referral and Consultation
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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