| Hereditary breast cancer syndromes and clinical implications. | |
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MedLine Citation:
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PMID: 19027378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Breast cancer is the most common cancer in the UK, and a significant number of breast cancers are hereditary. Identification of BRCA1/2 genes and the high-risk patients for developing breast cancer would allow a better understanding of the natural history and pathogenesis of breast cancer. Genetically predisposed patients and their families are managed differently than sporadic cases. Management of these individuals is decided in a multidisciplinary setting, which includes medical oncologists, clinical geneticists, psychologists, breast surgeons, plastic and reconstructive surgeons, clinical nurses and family planning specialists. This article reviews and highlights the current knowledge of hereditary breast cancer syndromes, the clinical implications of carrying a genetic predisposition and how it influences the management of the patient and the effect it has on breast reconstructive surgery services. |
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Authors:
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E J Majdak-Paredes; F Fatah |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-11-21 |
Journal Detail:
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Title: Journal of plastic, reconstructive & aesthetic surgery : JPRAS Volume: 62 ISSN: 1878-0539 ISO Abbreviation: J Plast Reconstr Aesthet Surg Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-03-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101264239 Medline TA: J Plast Reconstr Aesthet Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 181-9 Citation Subset: IM |
Affiliation:
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Department of Plastic Surgery, St Thomas Hospital London, London, UK. ewamajdak@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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genetics*,
prevention & control Female Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease Genetic Testing / methods Humans Mammaplasty / methods Mastectomy / methods Mutation Neoplastic Syndromes, Hereditary / genetics*, prevention & control Protein-Serine-Threonine Kinases / genetics Radiotherapy, Adjuvant |
| Chemical | |
Reg. No./Substance:
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EC 2.7.1.11/checkpoint kinase 2; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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