Document Detail


Hereditary antithrombin III deficiency: case report and review of recent therapeutic advances.
MedLine Citation:
PMID:  3942133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report on a newly diagnosed family with hereditary antithrombin III deficiency, with thromboembolic complications in the propositus. Both the propositus and his asymptomatic sister had decreased plasma levels of antithrombin III antigen and activity (28-52% of normal with good agreement between functional and immunologic assays). The propositus developed deep venous thrombosis, followed by massive pulmonary emboli despite heparin therapy and was treated with streptokinase and heparin with excellent results. Shortly thereafter, small bowel obstruction required surgical intervention, and antithrombin III concentrate, recently available in the United States as an investigational new drug (I.N.D.), was administered with no postoperative thrombotic complications. He was subsequently asymptomatic while on warfarin prophylaxis but twice developed venous thrombosis when he failed to take warfarin. The addition of danazol therapy led to a sustained rise in the antithrombin III level. Each of these therapeutic approaches is discussed and the literature reviewed with emphasis on the newer agents--streptokinase, antithrombin III concentrate, and danazol.
Authors:
N Miller; M B Hultin; M Gounder; M H Zarrabi
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  21     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-02-07     Completed Date:  1986-02-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithrombin III / genetics,  therapeutic use
Antithrombin III Deficiency*
Danazol / therapeutic use
Humans
Male
Warfarin / therapeutic use
Grant Support
ID/Acronym/Agency:
HL24893/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
17230-88-5/Danazol; 81-81-2/Warfarin; 9000-94-6/Antithrombin III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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