Document Detail

Hereditary angioedema.
MedLine Citation:
PMID:  17039649     Owner:  NLM     Status:  MEDLINE    
Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by a C1-inhibitor deficiency. It is characterized by potentially life-threatening recurrent episodes of angioedema of the skin and mucosa. Several recent studies have further elucidated the immunology of HAE implicating bradykinin, the key mediator of the contact system. This article reviews the pathophysiology, subtypes, and clinical features of HAE. Therapeutic approaches for various clinical situations (emergency and prophylactic regimens) are also discussed.
Michael M Sachse; Amor Khachemoune; Kjetil K Guldbakke; Michael Kirschfink
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  5     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-16     Completed Date:  2006-11-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  848-52     Citation Subset:  IM    
Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
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MeSH Terms
Aminocaproic Acids / therapeutic use
Angioedema / classification,  diagnosis*,  genetics,  physiopathology,  therapy*
Danazol / therapeutic use
Emergency Treatment
Genetic Predisposition to Disease
Reg. No./Substance:
0/Aminocaproic Acids; 17230-88-5/Danazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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