| Hereditary angio-oedema. | |
| | |
MedLine Citation:
|
PMID: 22305226 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Hereditary angio-oedema is caused by a heterozygous deficiency of C1 inhibitor. This inhibitor regulates several inflammatory pathways, and patients with hereditary angio-oedema have intermittent cutaneous or mucosal swellings because of a failure to control local production of bradykinin. Swellings typically evolve in several hours and persist for a few days. In addition to orofacial angio-oedema, painless swellings affect peripheries, which causes disfigurement or interference with work and other activities of daily living. Angio-oedema affecting the gastrointestinal tract or abdominal viscera causes severe pain often with vomiting due to oedematous bowel obstruction. About 2% of swellings involve the larynx and can be fatal if untreated. About 50% of patients have laryngeal swellings that are potentially fatal despite prophylaxis. In this Seminar we review the clinical features, diagnosis, and management of hereditary angio-oedema, with specific emphasis on the new treatments available for acute swellings. |
| | |
Authors:
|
Hilary Longhurst; Marco Cicardi |
Related Documents
:
|
301616 - Shifting of the blood t:b lymphocyte ratio in myasthenia gravis patients after thymectomy. 2177036 - Xanthomatous change in tumours of glial origin. 2430416 - Vulval lichen sclerosus et atrophicus treated with etretinate (tigason). 20574606 - Correlation of immunological profile with phenotype and disease outcome in pemphigus. 19926616 - Acute appendicitis is characterised by local invasion with fusobacterium nucleatum/necr... 1902616 - Cerebral vasoreactivity and the prediction of outcome in severe traumatic brain lesions. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Lancet Volume: 379 ISSN: 1474-547X ISO Abbreviation: Lancet Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-02-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
|
Languages: eng Pagination: 474-81 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Immunology, Barts and The London National Health Service Trust, Whitechapel, London, UK. hilary.longhurst@bartsandthelondon.nhs.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Global malaria mortality between 1980 and 2010: a systematic analysis.
Next Document: Possible Pet-associated Baylisascariasis in Child, Canada.