| Hereditary angio-oedema: new clinical observations and autoimmune screening, complement and kallikrein-kinin analyses. | |
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MedLine Citation:
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PMID: 8568479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study clinical and laboratory manifestations of hereditary angio-oedema (HAE). SUBJECTS: Thirty-three affected members of a kindred of 63. RESULTS: Oedematous attacks in the skin, mucous membranes and gastrointestinal tract with fluid displacement were elicited by mental and physical stress, minor traumas, dental and surgical procedures, eruption of teeth, tonsillitis, pregnancies, and use of oestrogen-containing pills including menopausal substitution. Every adult woman with symptomatic HAE (n = 11) showed symptoms of urinary tract infections in conjunction with the attacks (P = 0.010), and also experienced more spontaneous abortions or premature labours (P = 0.037) than healthy relatives. Patients with HAE of both sexes more frequently reported heartburn or peptic ulcers (P = 0.002). Rheumatic complaints were reported by 53% of HAE patients and 12% of their unaffected relatives (P = 0.013), but biochemical screening for 18 autoantibodies and quantitation of immunoglobulins did not reveal statistically significant differences between the two groups. C3, prekallikrein, total kininogen, high molecular weight kininogen (HK), alpha-2-macroglobulin and factor XII were not significantly different in HAE patients. In contrast, levels of C1-INH and C4 were depressed and cleaved HK increased in patients compared to unaffected relatives. CONCLUSIONS: HAE manifests in a variety of ways, and may influence risk of spontaneous abortions and premature labour. |
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Authors:
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E W Nielsen; J T Gran; B Straume; O J Mellbye; H T Johansen; T E Mollnes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 239 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-03-05 Completed Date: 1996-03-05 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 119-30 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, Nordland Central Hospital, Bod?, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Angioedema / enzymology, genetics*, immunology*, therapy Autoimmune Diseases / enzymology, genetics*, immunology*, therapy Child Child, Preschool Complement System Proteins / metabolism* Cysteine Proteinase Inhibitors / metabolism* Female Humans Kallikreins / metabolism* Kininogens / metabolism* Male Middle Aged Pedigree Precipitating Factors Pregnancy Pregnancy Complications, Cardiovascular / etiology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Cysteine Proteinase Inhibitors; 0/Kininogens; 9007-36-7/Complement System Proteins; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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