Document Detail

Hereditary angio-oedema: new clinical observations and autoimmune screening, complement and kallikrein-kinin analyses.
MedLine Citation:
PMID:  8568479     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study clinical and laboratory manifestations of hereditary angio-oedema (HAE). SUBJECTS: Thirty-three affected members of a kindred of 63. RESULTS: Oedematous attacks in the skin, mucous membranes and gastrointestinal tract with fluid displacement were elicited by mental and physical stress, minor traumas, dental and surgical procedures, eruption of teeth, tonsillitis, pregnancies, and use of oestrogen-containing pills including menopausal substitution. Every adult woman with symptomatic HAE (n = 11) showed symptoms of urinary tract infections in conjunction with the attacks (P = 0.010), and also experienced more spontaneous abortions or premature labours (P = 0.037) than healthy relatives. Patients with HAE of both sexes more frequently reported heartburn or peptic ulcers (P = 0.002). Rheumatic complaints were reported by 53% of HAE patients and 12% of their unaffected relatives (P = 0.013), but biochemical screening for 18 autoantibodies and quantitation of immunoglobulins did not reveal statistically significant differences between the two groups. C3, prekallikrein, total kininogen, high molecular weight kininogen (HK), alpha-2-macroglobulin and factor XII were not significantly different in HAE patients. In contrast, levels of C1-INH and C4 were depressed and cleaved HK increased in patients compared to unaffected relatives. CONCLUSIONS: HAE manifests in a variety of ways, and may influence risk of spontaneous abortions and premature labour.
E W Nielsen; J T Gran; B Straume; O J Mellbye; H T Johansen; T E Mollnes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  239     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-03-05     Completed Date:  1996-03-05     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-30     Citation Subset:  IM    
Department of Anaesthesiology, Nordland Central Hospital, Bod?, Norway.
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MeSH Terms
Angioedema / enzymology,  genetics*,  immunology*,  therapy
Autoimmune Diseases / enzymology,  genetics*,  immunology*,  therapy
Child, Preschool
Complement System Proteins / metabolism*
Cysteine Proteinase Inhibitors / metabolism*
Kallikreins / metabolism*
Kininogens / metabolism*
Middle Aged
Precipitating Factors
Pregnancy Complications, Cardiovascular / etiology,  immunology
Reg. No./Substance:
0/Cysteine Proteinase Inhibitors; 0/Kininogens; 9007-36-7/Complement System Proteins; EC 3.4.21.-/Kallikreins

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