Document Detail


Herding Hippos: regulating growth in flies and man.
MedLine Citation:
PMID:  19846288     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Control of cell number requires the coordinate regulation of cell proliferation and cell death. Studies in both the fly and mouse have identified the Hippo kinase pathway as a key signaling pathway that controls cell proliferation and apoptosis. Several studies have implicated the Hippo pathway in a variety of cancers. Recent studies have also revealed a role for the Hippo pathway in the control of cell fate decisions during development. In this review, we will cover the current model of Hippo signaling in development. We will explore the differences between the Hippo pathway in invertebrates and mammals, and focus on recent advances in understanding how this conserved pathway is regulated.
Authors:
Caroline Badouel; Ankush Garg; Helen McNeill
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Publication Detail:
Type:  Journal Article     Date:  2009-10-19
Journal Detail:
Title:  Current opinion in cell biology     Volume:  21     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-43     Citation Subset:  IM    
Affiliation:
Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Canada.
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